2-噁唑啉聚合物刷表面拓扑结构的设计制备与生物响应行为的研究

From the point of mimicking the structure of extracellular matrix, this project aims to invent a novel method to prepare polymer brushes with bottle brush-like structures on semiconductor through the formation of stable Si-C bond between a silicon substrate and poly(2-isopropenyl-2-oxazoline) chains, from which a second grafting polymerization of 2-oxaozlines occurs forming side chains; The nano/micro structure, morphology, hydrophilicity/hydrophobicity and cytotoxicity of the polymer brushes will be systematically investigated, and the effect of chemical composition, chirality of poly(2-oxazoline) side chains, thermo-responsiveness, superficial charge and the topological structure of the polymer brushes on the protein adsorption and cell adhesion behavior will be demonstrated, providing technical support for the design and preparation of biocompatible materials, and facilitating understanding of the bioadsorption on the surface/interface of materials.

本项目从模拟细胞外基质结构的角度出发，拟开发一种无需引发剂固载，通过形成稳定Si-C键在半导体硅片表面接枝聚2-异丙烯基-2-噁唑啉刷，经2-噁唑啉单体在聚合物刷主链的二次接枝聚合，获得具有'瓶刷'结构聚2-噁唑啉刷制备的新方法；阐明其微纳结构、表面形貌、亲疏水性与细胞毒性等特征，揭示聚合物刷的化学组分、侧链手性、温敏性、表面电荷、表面拓扑结构等参数对表面的蛋白质吸附及其诱导的细胞黏附行为的影响规律，为新型生物相容型材料的设计制备提供技术支持，以及对材料表/界面生物吸附行为的理解提供新的认识。

本项目从结构设计出发，建立了一系列基于光引发聚合、催化聚合等聚合技术的表面引发聚合方法，通过形成稳定共价键在半导体硅片等基底表面获得了各种成分的聚合物刷，通过控制反应时间、光强等实验条件，制备了具有不同层厚、接枝密度、拓扑结构的均聚物与共聚物刷，并建立了所制备聚合物刷的组成、结构、形貌与性能之间的关系，进一步探索了所获得的聚合物刷在催化、纳米材料制备与光热疗法方面的应用。