新疆地域性特殊证候与不同民族心血管衰老时序变化规律的关联研究

Northwest Dryness Syndrome (NDS) is the Xinjiang regional special syndrome, this syndrome are the main regional representation in Xinjiang about sub-health state. it involved a series of symptoms but not included modern medicine disease, it also influenced the morbidity and pathological changes course of high prevalence cardiovascular disease including Hypertension and Coronary Heart Disease (CHD) in Xinjiang, and become one of inducements and clinical representations of these diseases, it revealed the correlation between Northwest Dryness Syndrome (NDS) with cardiovascular aging mechanism. the medical communication have attended that there are multiple cardiovascular diseases and different incidence in different ethnic groups in Xinjiang, the common reason of these multiple diseases is correlative with effection of environment and climate, it is obviously that there are some special pathogenesis in Xinjiang. this study will develop on association study of the Xinjiang regional special syndrome with regularity of temporal changes for cardiovascular aging in different ethnic groups. using methods of metrology, traditional literature research and mathematical statistics etc, combining of microscopical means of modern medicine and macroscopical means of traditional chinese medicine, screening out cardiovascular aging biomarkers, from epidemiology, prevention and treatment of cardiovascular disease, combining the results of Northwest Dryness Syndrome (NDS). to reveal the infections and correlations on regularity of cardiovascular aging in different ethnic groups with special geographical environment and climate in Xinjiang. provide a reliable basis and useful references for further exploring the prevention and cure of cardiovascular disease in Xinjiang from the angle of treating different diseases with the same method.

新疆地域性特殊证候"西北燥证"是新疆人群亚健康状态的主要地域性表现；该组证候可以是一系列症状而不涉及现代医学既定疾病, 也可影响诸如高血压、冠心病等新疆多发心血管病的发病和病变过程,成为这些疾病诱因和临床表现之一，显示西北燥证与心血管衰老机制间存在相关关系。新疆医学界久已注意本地区存在心血管病高发且不同民族间发病率明显差异的问题,而气候环境影响显示该类疾病具有多发倾向的共同原因，显然存在具有新疆特殊性的致病因素。本课题拟从新疆不同民族心血管衰老及心血管病防治实际出发，结合西北燥证相关研究成果，采用计量辨证方法、文献学及中医传统理论方法、数理统计学方法，把中医的宏观与现代医学的微观结合起来，筛选心血管衰老生物学标志物，进行新疆地域性特殊证候与不同民族心血管衰老时序变化规律的关联研究，认清新疆特殊地理气候特点对不同民族心血管衰老规律的影响及相关关系，为从异病同治探索新疆心血管病防治策略奠定基础

新疆地域性特殊证候“西北燥证”是新疆人群亚健康状态的主要地域性表现；新疆医学界久已注意本地区存在心血管病高发且不同民族间发病率明显差异,本项目从新疆不同民族心血管衰老及心血管病防治实际出发，结合西北燥证相关研究成果，采用计量辨证方法、文献学及中医传统理论方法、数理统计学方法，进行新疆地域性特殊证候与不同民族心血管衰老时序变化规律的关联研究。研究资料分析显示：1.可作为心血管衰老相关生物学标志物的指标有：（1）血压相关指标：SBP、DBP、PP、PPI；（2）糖脂代谢指标：GLU、TC、TG、HDL-C、LDL-C；（3）肾功能指标：BUN、Cr、UA、Cys-C；（4）炎性指标：FIB；（5）心脏彩超指标：AD、LVDd、LVDs、LVEF。（6）颈部血管超声指标：IMT、D、RI、、EDV、PSV、D、RI、PSV等。2.心血管衰老相关指标中SBP、PP、GLU、LDL-C、BUN、Cr、UA、Cys-C、FIB、AD、LA、LVDd、LVDs、RA、RV、PA、IMT、RI等指标随着年龄的增长均呈上升趋势，三民族HDL-C、LVEF、EDV指标随着年龄增长则逐渐减低；提示维哈汉三个民族随着年龄增长，心血管衰老逐渐进展，但维哈汉三个民族心血管衰老进程规律存在差异，且同一地区不同民族之间比较，以及相同民族不同地区之间比较，心血管衰老进程均存在差异。3.新疆喀什、乌鲁木齐、伊犁三地区汉族总体西北燥证罹患率及西北燥证罹患程度均较维吾尔族及哈萨克族为重；维哈汉三个民族西北燥证罹患率随年龄增长均呈升高趋势；三民族燥证组心血管衰老进展均较非燥证组为快，三民族西北燥证主症积分与心血管衰老相关指标（如GLU、RV、DBP、LDL-C等）存在明显相关，提示西北燥证是影响维哈汉不同民族心血管衰老进程的一个加重因素。4. 乌鲁木齐地区维汉民族调查样本，10个虚证证候中气虚证、阳虚证、心虚证、肺虚证及肾虚证积分与年龄均存在相关性，其中肾虚证与年龄相关性最强，肾虚证与心血管衰老相关性最为显著。研究结果证明：新疆地区心血管衰老的生物学机制存在着不同于内地的特殊性，新疆特殊地理气候特点对不同民族心血管衰老进程及规律存在影响，西北燥证与心血管衰老机制之间存在相关关系，这为从异病同治探索新疆心血管衰老及心血管病防治策略奠定基础。