含氟砌块法合成含氟(稠)杂环类化合物的方法学研究

The heterocyclic compounds constitute a large group of natural products,special materials and synthetic drugs.A lot of studies had shown that the biological activities were normally strengthened significantly in the cases if fluorine element or fluoroalkyl group was introduced into molecules. However,synthesis of fluorinated heterocyclic, especially fluorine-containing fused heterocyclic compounds, as well as research on structure-activity relationship of the compounds and its application is still in the course of the study.The main content of this project will be based on our original work about fluorinated building blocks.First,we plan to improve the synthetic method of fluorinated alkyl keto esters and develop a new way to synthesize the fluorinated alkyl nitrogen-containing heterocyclic blocks;second,build up a concise and general synthetic route towards many kinds of fluoroalkyl substituted heterocyclic ring skeletons from w-fluoroalkylated ketoesters or other fluorine containing compounds as efficient fluorine containing building blocks.Furthermore, we will explore the usage of these synthesized compounds on OLED materials or antiepileptic、antidepressant drugs.

杂环化合物是天然产物、特种材料及合成药物的重要组成部分。大量研究结果表明：在有机化合物中适当的位置引入氟原子或含氟官能团后，往往能提高其生理活性。含氟杂环，尤其是含氟稠杂环类化合物的合成方法、化合物的构效关系及其应用研究尚处于研究过程之中。本项目研究内容主要在课题组原有含氟化合物设计合成工作基础上，从完善含氟砌块合成方法入手，发展以含氟烷基酮酸酯及含氟烷基氮杂环为含氟砌块的含氟稠杂环化合物的合成方法，建立一套简易便利、适用性广的含氟(稠)杂环化合物的合成方法。在此基础上，研究此类化合物在材料及药物等方面的应用。

杂环化合物是天然产物、特种材料及合成药物的重要组成部分。大量研究结果表明：在有机化合物中适当的位置引入氟原子或含氟官能团后，往往能提高其生理活性。含氟杂环，尤其是含氟稠杂环类化合物的合成方法、化合物的构效关系及其应用研究尚处于研究过程之中。本项目研究内容主要在课题组原有含氟化合物设计合成工作基础上，从完善含氟砌块合成方法入手，发展以含氟烷基酮酸酯及含氟烷基氮杂环为含氟砌块的含氟稠杂环化合物的合成方法，建立一套简易便利、适用性广的含氟(稠)杂环化合物的合成方法。在此基础上，研究此类化合物在材料及药物等方面的应用