永磁FePt弹簧圈导向纳米磁微粒栓塞动静脉瘘和动脉瘤的基础研究

Intracranial vascular lesions is the first cause of human disability, although endovascular treatment of aneurysms, arteriovenous fistula and arteriovenous malformations can lend to make improvement on prognosis , there are still different recurrence rate and technical complications. Animal experiments have confirmed that the nano-magnetic particles can be gathered in the target area under the action of an external magnetic field, especially for a certain effect on malignant cancer. However, the magnetic field required dedicated equipment, in particular researchs on focusing magnetic field are limited to the mathematical model, which greatly limit the use of magnetic targeted drugs delivery system. On the basis of existing research, it is easy to make the rabbit as the experimental object of the arteriovenous fistula, aneurysm model and to determine the parameters in the vivo fluid dynamics. By the improvements on high magnetic response FeNi3 nanoparticles and the different intensity of FePt permanent magnetic coil, FePt coils are transported into a lesion by the minimally invasive implantation , Owing to FePt coil with the local magnetic blocked-effect, arteriovenous fistula and aneurysm are embolized by nano-magnetic particles,which is expected to overcome complications of the previous embolic material such as vascular cell toxicity and sticking tube, and low packing density.

颅内血管性病变是导致人类致残的第一原因，目前介入治疗动脉瘤、动静脉瘘及动静脉畸形，虽然对改善愈合有一定效果，都有不同程度复发率和技术相关并发症。动物试验已经证实纳米磁微粒在外加磁场的作用下可以聚集在靶区，尤其对恶性肿瘤治疗已取得一定疗效。但目前外加磁场要求设备高，尤其聚焦磁场仅限在数学模型研究，大大限制纳米磁微粒的靶向治疗。本研究在已有的研究基础上，以兔为实验对象，利用其易制成动静脉瘘、动脉瘤的模型，了解在体流体动力学的参数。通过改进制成高磁响应的FeNi3纳米微粒和不同强度FePt永磁弹簧圈，以微创介入方法将弹簧圈植入到病变部位，利用FePt弹簧圈提供局部磁阻滞效应，，导向纳米磁微粒栓塞动静脉瘘和动脉瘤。可望克服以往栓塞材料的血管细胞毒性、粘管，以及单存弹簧圈闭塞率低的问题。