PM2.5对微粒水平的影响及其在PM2.5导致心血管损伤中的作用

With the development of the economy of our country, air pollution has been becoming a major threaten for public health in China. Previous studies showed that damage to the cardiovascular system is the main reason for the increased mortality caused by PM2.5. But so far, the exact mechanism of PM2.5 contributing to increased cardiovascular diseases is still not clear. Microparticles (MPs) is one of the research hotspot in the field of cardiovascular disease. MPs are vesicles whose diameter ranged from 0.1-1μm. They are released by different cells when they are activated or damaged. Microparticles are not only markers, but also participate the pathophysiologic pathways of cardiavascular disease such as inflammation, cell survival and apoptosis, endothelial cell dysfunction, blood vessel remodeling, angiogenesis, and thrombosis. Based on these findings, we speculate that microparticles played an important role in cardiovascular injury caused by PM2.5. Local injury in the lung caused by PM2.5 may lead to increased MP release, ultimately resulting in the impairment of the cardiovascular system. In this study, we will try to explore the relationship between the PM2.5 exposure and the level of different cell-derived MPs in health volunteers, and the impact of the MPs on endothelial cell function and inflammation, plaque stability and thrombosis. This will help us to better understand the mechanism of PM2.5 causing cardiovascular disease, as well as the potential intervention target.

随着我国社会经济的发展和人民生活方式的改变，空气污染日益成为影响人们身体健康与生命安全的重大公共问题。心血管系统损伤是可入肺颗粒物（PM2.5）导致死亡率增加的主要直接原因。但到目前为止，PM2.5促发心血管疾病发病的确切机制并不清楚。微粒是目前心血管领域的研究热点。微粒不仅仅是细胞激活或者损伤的标记物，更是参与并影响了诸如炎症、细胞的生存与凋亡、内皮功能、血管重塑以及新生血管生成、血栓形成等一系列病理生理过程。我们推测微粒可能在PM2.5导致的心血管损伤中发挥了重要作用。PM2.5对肺局部的损伤，可能导致微粒释放增加，最终造成心血管系统损伤。本研究将探讨不同 MP2.5 暴露水平下健康人血液中不同细胞来源的微粒水平及其促凝活性的变化，及这些微粒对内皮细胞功能、增殖、凋亡的影响，为明确PM2.5导致心血管疾病的机制及如何干预此过程提供研究证据。

随着我国社会经济的发展和人民生活方式的改变，空气污染日益成为影响人们身体健康与生命安全的重大公共问题。心血管系统损伤是可入肺颗粒物(PM2.5)导致死亡率增加的 主要直接原因。但到目前为止，PM2.5促发心血管疾病发病的确切机制并不清楚。微粒是目前心血管领域的研究热点。微粒不仅仅是细胞激活或者损伤的标记物，更是参与并影响了诸如炎症、细胞的生存与凋亡、内皮功能、血管重塑以及新生血管生成、血栓形成等一系列病理生理过程。我们推测微粒可能在PM2.5导致的心血管损伤中发挥了重要作用。本研究监测了不同PM2.5暴露水平下健康人血液中不同细胞来源的微粒水平的变化，以及微粒对平滑肌细胞的影响。研究显示，PM2.5暴露可对健康人的循环中微粒水平产生显著影响。我们的研究进一步显示，循环中微粒可能对血管平滑肌细胞的迁移产生影响，这可能是微粒影响心血管健康等机制之一，可能为防止PM2.5对健康的影响提供干预靶点。