环境响应性多孔纳米胶囊的构筑及其性能研究

The development direction of nanocapsules has been shifting from controlling nanocapsules’ walls and sizes to make nanocapsules with environmentally- responsive functionality. Environmentally- responsive nanocapsules can improve its transmission efficiency when nanocapsules achieve their targeted objectives. In this project, we hope to fabricate environmentally-responsive porous nanocapsules by polymer self-assembly method. We will use the designed and synthetic multi-compartment graft copolymers to self-assemble environmentally- responsive porous nanocapsules. We will tune the compartment and structure of graft copolymers to make the nanocapsules with both environmentally-responsive and porous functionality. We will continue to study the performance of nanocapsules, such as stability, environmentally-response, pore, and permeability. The research in this project will improve nanocapsules use’s value and prospects. It will break through the traditional ideas of making nanocapsules, set novel design principle and implementation routes for making multi-functional porous nanocapsules and provide sufficient scientific evidence for the further development of multi-functional nanocapsules..

纳米胶囊的制备正从传统的只强调控制纳米胶囊壁厚及尺寸向环境响应性多功能化的方向发展。环境响应性纳米胶囊可提高纳米胶囊的传输效率达到有的放矢的目的。本项目拟通过大分子自组装方法构筑环境响应性多孔纳米胶囊。将以多元结构接枝共聚物设计和合成为起点，把多元结构接枝共聚物分散在选择性溶剂中自组装形成纳米胶囊，通过有效调节多元结构接枝共聚物组成和结构，将纳米胶囊响应和多孔的双重特性有机给合在一起，从而达到构筑环境响应性多孔纳米胶囊目的。在此基础上，进一步研究纳米胶囊的稳定性、响应性、多孔性、渗透性等性能。本项目研究将有助于提升纳米胶囊的应用价值和前景。将突破纳米胶囊的传统制备思路，为构筑智能型多孔纳米胶囊体系设立了新的设计原理和实现途径，将为智能型纳米胶囊的进一步发展提供充分的科学依据。

本项目以多元结构接枝共聚物设计和合成为起点，把多元结构接枝共聚物分散在选择性溶剂中自组装形成纳米聚集体，通过有效调节多元结构接枝共聚物组成和结构，可获得单分子纳米胶束及纳米多孔胶囊。单分子纳米胶束的粒径约13 nm，可通过溶剂组成和配比，获得项链状，蠕虫状和球状结构。构筑的纳米多孔胶囊粒径约130 nm, 具有酸敏特性，当溶剂pH 变为酸性后，紫外光交联后的的纳米胶囊会在胶囊壁上出现5-10nm 的孔道。此多孔纳米胶囊可用于酸性条件下的可控释放。本项目研究构筑单分子纳米胶束及智能型多孔纳米胶囊体系设立了新的设计原理和实现途径，将为智能型纳米胶囊的进一步发展提供充分的科学依据。