基于微分相衬和散射衬度成像机制的多衬度X射线全场显微成像方法研究

In the next future significant advancements in materials science and life sciences will be possible only performing researches able to return information about the relationship between materials structure, function and nature. As a consequence, the combination of quantitative absorption information, phase information and the scattering information within the same experimental setup is an urgent demand for many scientific and technological researches. At present, available X-ray phase contrast microscopes is almost impossible providing the quantitative absorption information ,quantitative phase information and the scattering information, a condition that significantly limits x-ray microscopy applications in many research areas and applications.The proposal is based on the Beijing Synchrotron Radiation full field X-ray imaging microscope setup .according to X-ray microscopy study combined with differential phase contrast imaging and scattering mechanisms.Three-dimensional quantitative absorption information, phase information and the scattering information will be obtained by means of a new multi-element separation algorithm and an CT reconstruction algorithm. Based on the depth study of the X-ray microscopy theory ,this project will develop an innovative imaging technology and a reliable experimental platform useful for a full field x-ray microscope with independent proprietary intellectual property rights. When completed, the instrument will provide a unique powerful research tool to achieve a significant progress in materials science and life sciences with an important impact in many research areas and technological applications.

把样品的三维吸收信息、相位信息和散射信息结合起来，研究物质结构、功能和性质之间的相互关系，是材料科学和生命科学发展的迫切需求。然而，现有的纳米分辨X射线全场显微成像技术难以解决样品的吸收信息和相位信息的分离以及定量化获取的问题，同时无法实现散射信息的同时获得和无缝融合。本项目拟基于北京同步辐射纳米分辨X射线全场显微成像设备，通过深入研究基于微分相位衬度和散射衬度成像机制的多衬度X射线全场显微成像理论，从而发展和建立一套基于环形刀片扫描的硬X射线全场显微成像技术、以及信息分离算法和CT重建算法，最终实现样品的定量三维吸收信息、三维相位信息和三维散射信息的同时获得。该项目的开展将创新性的建立一套具有自主知识产权的基于微分相位衬度和散射衬度成像机制的多衬度X射线显微成像技术和实验平台，为材料科学、生命科学的发展提供更有利的研究手段，具有重要的科学意义和广泛的应用前景。

现有的纳米分辨X射线全场显微术成像技术只能分别获得单一、有限的三维结构信息，难以实现吸收信息、相位信息和散射信息的同时获得和无缝融合。本项目基于北京同步辐射纳米分辨X射线全场显微成像设备，深入研究基于微分相位衬度和散射成像机制的硬X射线全场显微成像理论，发展和建立基于环形刀片扫描的硬X射线全场显微成像技术、以及信息分离算法和CT重建算法，最终实现样品的定量的三维吸收信息、相位信息和三维散射信息的同时获得. 该项目的顺利完成有利的推动了X射线显微成像理论的完善和相关实验平台的建设，为材料科学、生命科学的发展提供更有利的研究手段，具有重要的科学意义和广泛的应用前景。.