同步辐射显微红外光谱及成像诊断胃癌的新方法研究

Cancer threatens human beings’ life and health seriously. Since early diagnosis and timely treatment of cancer can control cancer effectively, the development of new methods for cancer diagnosis has extremely important value for diagnosing and treating early cancer clinically. Human hair is easy to obtain and can reflect human beings’ serious diseases, synchrotron radiation infrared (SR-IR) microspectroscopy and imaging can accurately reveal the hair’s chemical compositions and their corresponding spatial distribution, so we want to develop a new method for early diagnosis of cancer from investigating gastric cancer patients' hair with SR-IR microspectroscopy and imaging. In this study, we will establish a simple and rapid experimental methodology for obtaining hair’s SR-IR micro-spectra and imaging at first, then we will detect hair based on this and explore: 1. the differences of main organic chemical compositions among gastric cancer patients’, precancerous disease (chronic atrophic gastritis, gastric ulcer) patients’ and healthy persons’ hair; 2. the differences of main organic chemical compositions among gastric cancer patients’ and the other digestive system cancer (esophageal cancer, colorectal cancer, liver cancer, pancreatic cancer, gallbladder cancer) patients’ hair; 3. the relationship between main organic chemical compositions of gastric cancer patients’ hair and the corresponding pathological staging results. We hope this study will offer new ideas and methods for clinical diagnosis of cancer.

癌症严重威胁人类的生命健康。早期诊断癌症并及时治疗可以有效控制癌症，因此发展新的癌症诊断方法对癌症的临床早期诊断与治疗有着极其重要的价值。头发容易获取并能反映人体严重疾病，同步辐射显微红外光谱及成像能够准确获取头发的化学组成及空间分布，因此我们拟通过胃癌患者头发的同步辐射显微红外光谱及成像研究发展一种癌症早期诊断的新方法。本项目首先建立一套快速简便测试头发的同步辐射显微红外光谱及成像的实验方法学，在此基础上我们对头发进行快速检测并寻找：①胃癌患者、癌前疾病（慢性萎缩性胃炎与胃溃疡）患者与健康者头发的主要有机化学组成的差异；②胃癌患者与其它消化系统癌症（食管癌、结直肠癌、肝癌、胰腺癌与胆囊癌）患者头发的主要有机化学组成的差异；③胃癌患者头发的主要有机化学组成和相应病理分期结果的关系。希望本项目的开展可以为癌症的临床诊断提供新的思路与方法。

早期诊断癌症与及时治疗可以有效控制癌症，发展新的癌症诊断方法对癌症的临床早期诊断及治疗有着极其重要的价值。头发容易获取并能够反映人体严重疾病，同步辐射显微红外光谱及成像能够准确获取头发的化学组成及空间分布，因此本项目利用同步辐射显微红外光谱及成像研究头发以发展一种胃癌早期诊断的新方法。我们首先建立了一套快速简便测试头发的同步辐射显微红外光谱及成像的实验方法学，以此为基础对头发进行快速检测并获得：①胃癌患者、癌前疾病(慢性萎缩性胃炎与胃溃疡)患者与健康者头发的主要有机化学组成的差异；②胃癌患者与其它消化系统癌症(食管癌、结直肠癌、肝癌、胰腺癌与胆囊癌) 患者头发的主要有机化学组成的差异；③淋巴结转移与淋巴结未转移胃癌患者头发的主要有机化学组成的差异。此外我们发现头发medulla层的红外光谱结合判别分析及主成分分析可以较好地区分上述疾病。本项目发表SCI收录论文4篇，为胃癌的早期临床诊断提供了帮助。本项目建立的方法可以推广到研究其它癌症的早期诊断，也为国内同步辐射技术在医学领域的应用提供了一些有价值的基础工作。