超声微泡造影剂介导靶基因治疗梗死性血管病及机制研究
基本信息
结项摘要
超声波破坏携靶基因微泡造影剂治疗是一种新型的无创性基因转移技术。基本原理为：超声破坏微泡造影剂后，其产生的空化效应或机械作用可使细胞膜通透性增加、直径≤7μm的微血管破裂，内皮细胞间隙增宽。靶基因可通过破裂的微血管和内皮细胞间隙到达组织细胞。用超声波在特定组织击碎微泡，将提高基因治疗的靶向性和疗效。.梗死性血管病是临床常见病与多发病。梗死性血管病的基因治疗是重要的研究方向。本实验采用不同声强及频率
项目摘要
项目成果
{{i.achievement_title}}
{{i.achievement_title}}
暂无此项成果
数据更新时间：2023-05-31
其他相关文献
Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer’s disease
Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer’s disease
Quantification of Atherosclerotic Plaque Elasticity Using Ultrasonic Texture Matching
Quantification of Atherosclerotic Plaque Elasticity Using Ultrasonic Texture Matching
Safety evaluation of simultaneous resection of colorectal primary tumor and liver metastasis after neoadjuvant therapy: A propensity score matching analysis.
Safety evaluation of simultaneous resection of colorectal primary tumor and liver metastasis after neoadjuvant therapy: A propensity score matching analysis.
Neuroprotective Effect of Low-Intensity Transcranial Ultrasound Stimulation in Moderate Traumatic Brain Injury Rats
Neuroprotective Effect of Low-Intensity Transcranial Ultrasound Stimulation in Moderate Traumatic Brain Injury Rats
Transcriptome analysis provides insight into the role of the melanin pathway in two differently pigmented strains of the turtle Pelodiscus sinensis
Transcriptome analysis provides insight into the role of the melanin pathway in two differently pigmented strains of the turtle Pelodiscus sinensis
王志刚的其他基金
相似国自然基金
超声微泡造影剂携靶基因治疗及其声像图监控研究
超声微泡造影剂介导siRNA基因沉默与诱导双向组合式基因治疗椎间盘退变的实验研究
超声造影剂微泡靶向介导Her2-siRNA治疗乳腺癌的研究
微泡造影剂和共聚物P85在超声介导基因转染中的应用