超声微泡造影剂携靶基因治疗及其声像图监控研究
基本信息
结项摘要
超声波破坏携靶基因微泡造影剂治疗是一种新型的无创性基因转移技术。基本原理为：超声破坏微泡造影剂后，其产生的空化效应或机械作用可使细胞膜通透性增加、直径≤7μm的微血管破裂，内皮细胞间隙增宽。靶基因可通过破裂的微血管和内皮细胞间隙到达组织细胞。用超声波监控并在靶组织击碎微泡，将提高基因治疗的靶向性和疗效。针对当前基因治疗方法学的不足，本项目旨在通过动物和临床实验,为梗死性血管病、肝纤维化提供一种超声
项目摘要
项目成果
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数据更新时间：2023-05-31
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