空间学习记忆任务调控海马未成熟神经元选择性存活的意义与机制研究

The adult neurogenesis in hippocampus is critically related with brain function such as learning and memory, depression, etc. It is also reported that the reference memory tasks could promote survival of the new neurons of one week in hippocampus. Interestingly, we also found that the working memory tasks could decrease the survival of immature neuron. Therefore, it is of great interest to study the underlying mechanism for survival control of the immature neurons in hippocampus. In this project, we will study the how the survival and apoptosis of the immature neurons in hippocampus caused by learning and memory of the spatial learning tasks. We will further study the function of the selective survival of the immature neurons and to illustrate the underlying mechanism. Therefore, this project will probably reveal the importance of the adult neurogenesis in hippocampus and the possible mechanisms of learning and memory and contribute to the regulation strategy of plasticity of the brain.

海马中成年神经发生(adult neurogenesis)与学习记忆、抑郁等脑功能活动密切相关。既往研究发现参考记忆任务可促进海马新生一周左右未成熟神经元的存活，我们新近研究中发现工作记忆任务可降低未成熟神经的存活。结合目前国际上研究进展和我们前期实验基础，海马未成熟神经元受空间记忆任务刺激后选择凋亡或存活的现象激发我们对未成熟神经元在记忆中作用的强烈关注。为此，我们将研究空间学习记忆任务激活后，新生一周左右未成熟神经元的凋亡与存活的变化规律，探讨未成熟神经元选择性存活的功能作用，试图揭示空间学习记忆任务中未成熟神经元的选择性存活机制，预期将初步阐明海马中成年神经发生的功能意义以及学习记忆的部分机制，并为寻找脑可塑性变化调控策略提供重要参考资料。