多功能金纳米簇用于碳离子放射治疗诊疗一体化的应用基础研究

Both physical and biological advantages of carbon ion radiotherapy exist: when compared to photons, they provide beneficial dose distribution and, in the case of carbon ions being heavier than protons, larger relative biological effectiveness (RBE). Also, dose delivery accuracy and therapeutic effectiveness would be further improved when employing both more advanced contrast imaging strategies for tumor target volume delineation and radiosensitizers. As multifunctional fluorescent nanomaterials with ideal physicochemical properties and good biocompatibility, gold nanoclusters (AuNCs) may play a role in tumor imaging, image guidance as well as radiosensitization in radiation therapy (RT). Moreover, no studies have yet reported the radiosensitizing effects of AuNCs for carbon ions. In recent years, we have focused on the application of gold nanomaterials in radiation oncology and carried out several basic studies. Based on our previous work, this project intends to synthesize a series of multifunctional AuNCs and subsequently to explore the potential of applying AuNCs to cancer theranostics in carbon ion radiotherapy using breast cancer cells in vitro and tumor-bearing mice, as well as to address and interpret the basic and key issues such as tumor targeting capability and radiosensitization mechanisms of AuNCs. These investigations will provide the theoretical and experimental basis as well as the technical support for the possibility of AuNC translation into clinical practice.

碳离子放射治疗具备物理学和生物学两方面的优势：比光子更好的剂量适形性和较质子（比碳离子轻）更高的相对生物学效应。同时，更先进的肿瘤靶区对比成像方法和放射增敏剂可以进一步提高治疗精度及疗效。金纳米簇作为多功能的荧光纳米材料具备优良的理化特性和生物相容性，其在肿瘤放射治疗中可以用于肿瘤成像、图像引导和发挥放射增敏作用等；另外，金纳米簇对碳离子的放射增敏作用尚未被报道过。近年来，我们致力于金基纳米材料在放射肿瘤学中应用的基础研究。在已有的研究基础上，本项目拟合成一系列多功能金纳米簇，然后使用体外培养乳腺癌细胞和荷瘤小鼠探索金纳米簇在碳离子放射治疗诊疗一体化中应用的潜在价值并解决阐释所涉及的包括金纳米簇肿瘤靶向性和金纳米簇放射增敏机制等重要基本问题，通过以上研究为今后的临床应用提供理论依据、实验数据和技术支撑。

碳离子放射治疗具备物理学和生物学两方面的优势：比光子更好的剂量适形性和较质子（比碳离子轻）更高的相对生物学效应。同时，更先进的肿瘤靶区对比成像方法和放射增敏剂可以进一步提高治疗精度及疗效。金纳米簇作为多功能的荧光纳米材料具备优良的理化特性和生物相容性，其在肿瘤放射治疗中可以用于肿瘤成像、图像引导和发挥放射增敏作用等；另外，金纳米簇对碳离子的放射增敏作用尚未被报道过。近年来，我们致力于金基纳米材料在放射肿瘤学中应用的基础研究。在已有的研究基础上，本项目拟合成一系列多功能金纳米簇，然后使用体外培养乳腺癌细胞和荷瘤小鼠探索金纳米簇在碳离子放射治疗诊疗一体化中应用的潜在价值并解决阐释所涉及的包括金纳米簇肿瘤靶向性和金纳米簇放射增敏机制等重要基本问题，通过以上研究为今后的临床应用提供理论依据、实验数据和技术支撑。