壳聚糖纳米粒装载HP BabA2/UreI基因双价黏膜DNA疫苗的研究
基本信息
结项摘要
本项目选择HP的BabA2和UreI基因作为目的抗原联合应用，并利用壳聚糖具有黏膜佐剂效应和其纳米粒可作为基因载体的特性,以壳聚糖纳米粒装载含目的基因的质粒DNA，经粘膜免疫小鼠，研究以壳聚糖纳米粒为载体的HP DNA疫苗对HP感染的免疫保护和免疫治疗作用及其作用机理，并探索其最佳免疫途径。同时阐明用壳聚糖纳米粒装载的HP DNA疫苗可否克服裸DNA疫苗易被消化道环境破坏这一缺陷，增强HP DNA疫苗的免疫效应。为壳聚糖纳米粒作为HP DNA疫苗载体的应用提供理论和实验依据，并建立以壳聚糖纳米粒为载体的新型HP DNA，为HP感染的免疫防治开辟新的途径。
项目摘要
项目成果
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数据更新时间：2023-05-31
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