以TLR9为靶点研究青蒿素拮抗细菌DNA的作用机制
基本信息
结项摘要
细菌脓毒症是临床病人死亡的主要原因之一，寻找有效药物并阐明其作用机制具有重要意义。CpG DNA是脓毒症的主要致病因子，我们前期工作发现青蒿素对CpG DNA引起的脓毒症具有较好的治疗作用，但机制不清。因此，本研究拟在青蒿素对TLR9受体上游环节无明显影响的研究基础上，以TLR9为靶点，从以下层面研究青蒿素的作用机制：首先，采用RT-PCR和流式细胞术，观察青蒿素对CpG DNA诱导的TLR9 m
项目摘要
项目成果
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数据更新时间：2023-05-31
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