复合孔径限制和分子印迹的周期性介孔材料的合成及对胆红素吸附研究

Clearance and selectivity are two important indices to evaluate adsorption property. The bilirubin adsorbents generally show much smller bilirubin clearance in the plasma of patients than that in PBS solution, which may be due that the other components in the plasma occupy a part of binding sites of bilirubin and then decrease the clearance. Therefore, the target of this project is to increase the bilirubin clearance of adsorbent by increasing its selectivity. On one hand, the silica mesoporous materials have unique and tunable pore size.based on the character,a series of mesoprous silica materials with different pore size are synthesized. we will systematically study the effect of pore size on adsorption property, and then explore the optimization pore size for bilirubin adsorption. The optimization pore size of channels will permit the big molecules into the channels, and then reduce the effect of big molecules on the selectivity. On the other hand, molecule imprinting technology will be selected to improve the selectivity. The amide bond is used to link bilirubin molecule to 3-aminopropyltriethoxysilane at two points to generate covalently bound imprint precursor. This precursor is used as silica source to synthesize bilirubin imprinted periodic mesoporous orgaosilane materials with aboved optimization pore size. This project will investigate the metod of combination the pore size limitation and molecule imprinting technology, study their co-effect on increasing the selectivity, and provide new medical adsorbents and theory basis for design of new materials.

清除率和选择性是评价吸附性能的重要指标。相比于在PBS 溶液中，胆红素吸附剂在病人血浆中具有较小的胆红素清除率，这主要是血浆中其他成分占据了部分胆红素分子的结合位点进而导致清除率降低。因而，本项目拟聚焦于通过提高胆红素吸附剂的选择性进而提高清除率。首先，基于硅基介孔材料具有单一孔径且孔径连续可调的特点，合成系列具有不同孔径尺寸的硅基介孔材料。系统研究孔径尺寸对吸附性能的影响，探索吸附胆红素分子的优化孔径尺寸，优化的孔径尺寸将限制大尺寸分子进入孔道，减小其对吸附选择性的影响。其次，选用具有高选择性的分子印迹技术提高吸附选择性。利用酰胺键将胆红素分子和氨丙基三乙氧基硅烷合成分子印迹前驱体，并以此为硅源合成具有上述优化孔径尺寸的胆红素分子印迹周期性有机硅介孔材料。探索复合孔径尺寸限制和分子印迹技术的方法以及在提高胆红素吸附选择性中的协同作用，提供新型医用吸附剂和材料设计的理论。