rhBMP-2m对造血损伤修复的基因调控

The characters of hematopoietic injury with radiation and antitumor chemicals is infection and bleeding. It is because that the bone marrow and hematopoietic microenvironment were injury. Repairing damnified hematopoietic system is an important field in research of radiobiology.. Our focus is making clearly how rhBMP-2m made damnified hematopoietic system to repair? What 's mechanism of the gene regulating? We want to discover that the BMP-2m induce bone marrow multipotential adult progenitor cells to differentiate hematopoietic stem cells, to show multipotential adult progenitor cells can transform at special condition. Just the characteristic of multipotential adult progenitor cells, it may be a new theory, which will be used in therapy of acute radiation sickness and clinical hematopoietic disease..

本课题以动物放射损伤为模型，以申请者发现的rhBMP-2m能促进造血损伤修复，提高急性放射病动物活存率为线索，利用反义核酸和基因探针技术研究BMP对造血细胞增殖分化的基因骺兀鄄霣MP对骨髓造血干细胞及骨髓基质干细胞的影响及其关系，以期在BMP促造血调控矸矫嬗兴黄疲派洳『土俅惭翰〉仍煅鹕思膊〉闹瘟铺峁┬碌囊谰荨