基于稀土上转换-超顺磁性四氧化三铁Janus结构实现协同治疗

The early diagnosis and therapy of cancer cells is an urgent issue waiting to be conquered. This project tends to combine upconversion optical sensors and superparamagnetic Fe3O4 as a rod-shaped Janus structure which can be easily swallowed by living cells. Their individual characters can be well preserved without effecting each other. The upconversion emission peaks of different wavelengths are used as inner reference and excitation source to transfer its energy to luminescent complex probes. Cancer cells are expected to be imaged and identified through O2 concentration difference with normal ones and finally destroyed by photo therapy. Here, Fe3O4 is introduced to realize site-specific aggregation at lesions and thermal therapy under IR radiation. It is expected that high sensitivity, promising selectivity, good water-solubility, biocompatibility and co-therapy can be observed from such sensing systems. The results from this project can provide a simple method for the early diagnosis and auxiliary therapy in community infirmaries and underdeveloped regions.

癌细胞的早期诊断和治疗是目前迫切需要解决的问题。本项目拟利用Janus结构将上转换光学传感器与超顺磁性四氧化三铁组成易于被细胞吞噬的双功能纳米棒。该结构可在保留各自功能特性基础上有效地避免相互影响。利用上转换材料在不同波长下的特征发光分别作为内参比和激发光源激发发光配合物探针，通过对癌细胞与正常细胞之间氧气浓度的差异检测，实现对癌细胞的成像、识别和光动力学杀灭。通过Fe3O4实现Janus材料在病灶部位的富集，并在红外光的照射下完成对癌细胞的光热杀灭。该类材料兼具高灵敏度、高选择性、良好水溶性和生物相容性和对癌细胞的协同杀灭等特性，可为社区医院及医疗条件欠发达地区提供一种新的简便快速检测早期癌细胞和辅助治疗的技术手段。

癌细胞的早期诊断和治疗是目前迫切需要解决的问题。本项目拟利用Janus结构将上转换光学传感器与超顺磁性四氧化三铁组成易于被细胞吞噬的双功能纳米棒。该结构可在保留各自功能特性基础上有效地避免相互影响。利用上转换材料在不同波长下的特征发光分别作为内参比和激发光源激发发光配合物探针，通过对癌细胞与正常细胞之间氧气浓度的差异检测，实现对癌细胞的成像、识别和光动力学杀灭。通过Fe3O4实现Janus材料在病灶部位的富集，并在红外光的照射下完成对癌细胞的光热杀灭。该类材料兼具高灵敏度、高选择性、良好水溶性和生物相容性和对癌细胞的协同杀灭等特性，可为社区医院及医疗条件欠发达地区提供一种新的简便快速检测早期癌细胞和辅助治疗的技术手段。