采用理化复合技术降解发酵药渣中残留四环素机理的研究

Tetracycline fermentation with starch, soybean dregs, glucose, peptone as the main raw material for medium fermentation and extraction of drugs after the by-product, which is the main component of microbial mycelium, organic compounds, inorganic salt, (antibiotic residue, rich in protein and a variety of amino acid, crude protein content of 48% and above, is very valuable animal protein feed to develop raw material. However, due to the dregs contain trace amounts of residues, cannot be directly used as animal feed raw materials directly use, must undergo degradation.This project by tetracycline fermentation dregs and set the adding quantity of special chemical treatment agent at the same time into the improved intelligent mixing machine for processing, and then processing the dregs using special intelligent extruder processing, realize the effective degradation and fermentation residue in pharmaceutical tetracycline purposes, fermentation study of drug residue in tetracycline degradation kinetics and degradation mechanisms, elucidating the chemistry of physics composite processing method of fermentation residue in pharmaceutical tetracycline degradation mechanism, revealing its composite treatment technical parameters (processing agent content, temperature, pressure, time) were changed tetracycline structure law, as fermenting dregs harmless treatment to provide a new theoretical basis and the new thoughts.

四环素发酵药渣是以淀粉、豆粕、葡萄糖、蛋白胨为主要原料作培养基发酵提取药物后的副产品，其中主要成分是微生物菌丝体、有机物、无机盐、残留抗菌素、富含蛋白质和各种氨基酸，粗蛋白质含量在48%以上，是非常有价值的动物蛋白饲料待开发原料。但是，由于药渣含有微量的药残，不能直接作为动物饲料原料直接利用,必须进行降解。.本项目通过将四环素发酵药渣与设定添加量的特制化学处理剂同时置入改进的智能混合机中进行处理,然后再将处理后的药渣采用专用智能膨化机进行膨化处理，实现有效降解发酵药渣中残留四环素的目的，研究发酵药渣中残留四环素的降解动力学与降解机理，阐明化学物理复合处理方法降解发酵药渣中残留四环素的机理，揭示其复合处理技术参数(处理剂添加量、温度、压力、时间)分别改变四环素结构的规律，为发酵药渣的无害化处理提供新的理论依据和资源化利用的新思路。

四环素发酵药渣是以淀粉、葡萄糖、蛋白胨为主要原料作培养基发酵提取药物后的副产品，富含蛋白质和各种氨基酸，是非常有价值的动物蛋白饲料待开发原料。本项目以降解药渣中药残，促进药渣作为动物饲料原料为目的。以药渣中四环素为研究对象，根据其性质研制了特制化学处理剂（经过脱脂、脱胶、脱腊、脱酸处理的大豆油脂）和智能混合机特殊设备，同时建立了准确测量药渣中四环素的分析方法。分别采用化学处理-紫外法降解、物理膨化降解、过氧化氢降解方法，优化降解条件，考察降解效果，探讨降解性能，评价降解药渣毒性，总结相关规律，皆为四环素废弃药渣环保处理及资源化利用提供新的解决办法。项目研究成果发表论文2篇，其中SCI收录期刊1篇，授权专利1篇，达到了计划任务书规定的要求。随着后续实验数据的整理和完善，还会有更多的论文发表或专利。