何杰金氏病背景淋巴细胞的分子克隆性研究

Being based on the questions that whether the background cells of HD have clonality and what relation between the H/RS cell and its background cells,our research detected the expression of micropicked H/RS cells from paraffin-embedded sections and its background cells in protein、mRNA and DNA by molecular histology methods.This research would reveal the nature of the background cells and the relation with RS cell,so that we could give a new themry basis for earlier prevention、therapy、prognosis evaluation and the origin of RS cell.

鉴于对HD组织中R-S细胞的背景淋巴细胞是否有克隆性以及与R-S细胞有无相关性的认识存在质疑，本项目采用“分子组织学”方法，从组织切片上挑取单个R-S细胞，使其与背景淋巴赴挚酱拥鞍住RNA、DNA三水平对二者检测，揭示背景淋巴细胞的本质，证明与R-S细胞的相关，为HD的早期预测、治疗、预后评价及R-S细胞起源提供新的理论依据。