假丝酵母在有机介质中高选择性催化部分加氢反应的研究

Abstract Based on whole-cell biocatalysis for asymmetric synthesis in organic media,the solvent tolerance of some yeast were examined and a model for calculating activities retention of microbe in the presence of organic compounds was established.The asymmetric reductions of ethyl 4-chloroacetate,1-phenyl-1,2- propanedion ,geraniol and benaldehyde with baker's yeast in organic media were studied in detail.This research contributes to the applications of whole-cell biocatalysis in the field of chiral synthesis in theory and practice.

以探讨微生物活细胞在有机介质中催化有机反应，选择假丝酵母为模型微生物，以高选择性不饱和键部分加氢为模型反应，研究游离和固定化酵母在有机介质中对模型反应的催化作用，优化催化条件，为微生物在有机介质中高选择性催化的研究打下良好的基础，扩大有机介质生物催化的研究领域，形成新的学科生长点，展现有机介质生物催化的新方向。