基于免疫调控研究淫羊藿总黄酮治疗肾阳虚型干眼症的干预机制

Dry eye, is that because of the quality and quantity of the tear abnormal or tear fluid dynamics caused by abnormal tear film instability and the damage of ocular surface, leading to symptoms of ocular discomfort is a kind of disease. In recent years, its incidence is very high, has become a hot issue in the present study. Many studies suggest that dry eye is ocular surface disease autoimmune chronic inflammatory. In view of the existing drugs for a variety of reasons resulted in clinical use, a safe and effective therapeutic methods of TCM thinking, in the commonly used Chinese herbal medicine explore a plant immune suppressing drugs is a problem to be solved. Also Chinese medicine was mostly to treat Yin dry eye, can achieve a certain effect, but in clinical practice, often many patients with nourishing yin to moisten dryness, such as medicine, the effect is poor, symptoms did not improve, even heavier. Studies have shown that such patients from Yang and treatment can achieve good clinical efficacy. Epimedium is a strong flavoured Yang medicine, and proof of Epimedium Flavonoids (EF) by reshaping the T lymphocyte apoptosis related genes, significantly improve the role of immune cells. Therefore put forward the hypothesis: kidney yang deficiency can cause dry eye, total flavonoids of Herba Epimedii by immune mediated guide regulatory treatment of kidney yang deficiency syndrome.

干眼，是指因泪液质和量的异常或泪液液体动力学异常引起的泪膜不稳定及眼表损害，从而导致眼部不适症状的一类疾病。近年来其发病率很高，已成为目前研究的热问题。众多研究提示，干眼是眼表慢性的自身免疫性炎症性疾病。鉴于现有药物因各种原因导致在临床使用的限制性，思考一种安全有效的中医药治疗方法，在常用中草药中探求一种植物性免疫抑制药物，是亟待解决的课题。另外，中医大多以阴治干眼症，取得一定疗效,但在临床实践中,常有不少病人用养阴润燥之类的药,效果不佳,症状不见好转,甚至加重，研究表明此类患者从阳而治亦可取得较好的临床疗效。淫羊藿是一味强补阳之药，并有研究证淫羊藿总黄酮（Epimedium Flavonoids，EF）通过重塑T淋巴细胞凋亡相关基因，明显改善细胞免疫作用。由此提出假说：肾阳虚可致干眼症，淫羊藿总黄酮通过免疫介导调控治疗肾阳虚型干眼症。

干眼，是指因泪液质和量的异常或泪液液体动力学异常引起的泪膜不稳定及眼表损害，从而导致眼部不适症状的一类疾病。近年来其发病率很高，已成为目前研究的热门问题。众多研究提示，干眼是眼表慢性的自身免疫性炎症性疾病。鉴于现有药物因各种原因导致在临床使用的限制性，思考一种安全有效的中医药治疗方法，在常用中草药中探求一种植物性免疫抑制药物，是亟待解决的课题。另外，中医大多以阴治干眼症，取得一定疗效,但在临床实践中,常有不少病人用养阴润燥之类的药,效果不佳,症状不见好转,甚至加重，研究表明此类患者从阳而治亦可取得较好的临床疗效。淫羊藿是一味强补阳之药，并有研究证淫羊藿总黄酮（Epimedium Flavonoids，EF）通过重塑T淋巴细胞凋亡相关基因，明显改善细胞免疫作用。由此提出假说：肾阳虚可致干眼症，淫羊藿总黄酮可通过免疫介导调控治疗肾阳虚型干眼症。经过本项目实验发现，淫羊藿总黄酮可以通过抗炎、抑制免疫、抑制雄激素等作用治疗干眼症，特别是对于肾阳虚型干眼症，为干眼探求了一种新的、有效针对病因的中药免疫抑制药物，为中医治疗干眼症提供了理论支持，为中医辨证论治提供了现代科学依据。