NF-κB Decoy ODNs 纳米粒抗炎效应实验研究
基本信息
结项摘要
本研究将纳米技术与转录因子Decoy策略有机结合起来，以具有良好生物相容性且可生物降解的聚氰基丙烯酸酯为纳米载体，制备NF-κB Decoy ODNs纳米粒，从而有效解决Decoy ODNs易被核酸酶降解及进入靶细胞核内量少的这一难题。并通过体外拮抗炎症介质生成、体内抗炎效果的动物实验验证，最终获得对NF-κB 驱动的炎症反应具有高效拮抗作用的Decoy ODNs纳米粒。
项目摘要
项目成果
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数据更新时间：2023-05-31
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罗艳的其他基金
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