介入超声肾去交感化安全性探索

Renal sympathetic denervation (RSD) has showed broad prospect for the treatment of hypertension, heart failure, arrhythmia and glucose metabolism. However, there were worries about the vessel damage and uncontrollable ablation degree using present energy resource and ablation strategy, which ablated the renal artery helically utilizing RF catheter. In order to get a more controllable RSD level, we expect to obtain a visible ablation progress using a multifunctional ultrasound catheter devoloped by our laboratory. What's more, in this study, it will study the adjustment ability of the body response to hemorrhage stress after complete RSD and investigate the level of denervation for the basic anti-stress ability maintaining, and these results will provide experimental basis for the treatment of hypertension by interventional ultrasound energy RSD safety and effectively which would promote the research and development of the home-made medical high-tec intervention instrument with.

肾去交感化（RSD）对高血压、心衰、糖代谢紊乱等现代生活方式相关疾病的治疗表现出富有希望的广阔前景，但目前使用的射频电极导管螺旋形消融的能量和方式存在肾动脉损伤和去交感化程度难以控制的问题。文献及我们的前期工作表明，使用较低的超声能量能够达到选择性肾去交感化。为更好控制RSD消融程度，项目拟用自主研发的多功能超声导管实现超声影像可视化的消融，获得创新性的可控超声消融RSD方法。项目还将深入研究完全RSD后机体对失血应激调节能力的改变，并进一步探讨维持一定肾交感活性对血流动力学代偿的作用和肾去交感化的机体具有应激能力的安全程度，为实现安全高效可控的介入超声RSD治疗高血压及相关疾病提供理论及实验基础，同时也促进国产高技术RSD介入器械的研发。

项目针对目前去肾脏交感神经（RDN）治疗中存在的问题，包括：射频消融引起肾血管损伤、RDN程度难以控制、消融靶点的缺失等，自主研制了一款具备血管内超声成像和高频超声消融功能的可视化超声导管，获取创新性和可控超声超声消融RDN的方法。项目探索了不同超声参数组合、不同消融术式对交感神经的损伤程度及RDN治疗效果，并基于血管内超声成像技术，探索不同交感损伤程度对于机体交感张力及应激能力的改变。项目研究中，研制了多代具有自主知识产权的国产RDN微创介入医疗器械，初步获取了适合于RDN的术式及超声参数，以及维持一定肾交感活性的机体具有应激能力的安全程度，为实现安全、高效可控的介入超声RDN治疗高血压及相关疾病提供了一些理论及实验基础，同时也促进了国产高技术RDN器械的研发。