近红外光响应和肿瘤渗透性纳米药物载体的构建及用于肿瘤的光动力免疫治疗

Because of the severe side effects in the practical application of the current tumor treatment, photodynamic therapy and immunotherapy was combined to enhance cancer therapy. Meanwhile, based on the fact that nanoparticle drug delivery system has shown greatly enhanced chemotherapy efficient for cancer therapy, this proposal focuses on the development of nanoparticles as targeted drug carriers for smart drug release. We plan to design a multi-function drug delivery system and use in photosensitizer and immune adjuvant delivery. This drug delivery system combines photodynamic therapy and immunotherapy to improve cancer treatment efficacy. The nano drug delivery system was modified with iRGD which could enhance the tumor targetability and tumor-Penetrating ability of the delivery system. The drug delivery system could realize precise smart drug release upon NIR irradiation. Finally, tumor was treated by Photodynamic Immunotherapy. This combination therapy will provide a new strategy for more efficient treatment of cancer.

针对当前肿瘤治疗方式在实际应用中所存在的问题，采用光动力治疗和免疫治疗联合的方式实现肿瘤的有效治疗。同时，针对药物靶向传递和智能控释的关键科学问题，设计制备多功能的纳米药物载体用于对光敏药物和免疫佐剂的共传输。通过iRGD修饰提高纳米药物载体的肿瘤靶向性和实现肿瘤组织的有效渗透；通过设计近红外光响应纳米药物载体，利用近红外光较强的组织穿透力，实现药物的精确释放；依据光敏药物和免疫佐剂协同增效的特点，实现对肿瘤的光动力免疫治疗。探索构建基于肿瘤靶向和肿瘤组织渗透、多药协同增效以及药物控释的新型纳米药物载体系统，为肿瘤治疗手段的优化和突破提供依据。

针对当前肿瘤治疗方式在实际应用中所存在的问题，采用光动力治疗和免疫治疗联合的方式实现肿瘤的有效治疗。同时，针对药物靶向传递和智能控释的关键科学问题，设计制备多功能的纳米药物载体用于对光敏药物和免疫佐剂的共传输。通过iRGD修饰提高纳米药物载体的肿瘤靶向性和实现肿瘤组织的有效渗透；通过设计近红外光响应纳米药物载体，利用近红外光较强的组织穿透力，实现药物的精确释放；依据光敏药物和免疫佐剂协同增效的特点，实现对肿瘤的光动力免疫治疗。探索构建基于肿瘤靶向和肿瘤组织渗透、多药协同增效以及药物控释的新型纳米药物载体系统，为肿瘤治疗手段的优化和突破提供依据。