核动力舰艇核辐射危害防护应用基础研究

As one of the most prioritized fighting platforms, Nuclear-powered warship also brings about many harzards of high linear energy transfer (LET) particles. Nowadays, there are few effective protecting strategies against high LET radiation in our country, which is also urgently required by our army. To develop novel strategies and techniques against high LET radiation is critical for the maintenance of human health, saving lifes of the injuried soldiers and ensuring high combat effectiveness. It is also an inevitable and pressing problem for developing a strong navy and making our nation a very powerful country in marine affairs. This study is aimed to solve this major problem. Based on the high LET-simulated experimental platform in the Institute of Modern Physics, Chinese Academy of Sciences in Lanzhou, We will select novel and potential radioprotectors (including Toll like receptors ligands, molecular hydrogen, antioxidant etc.) from our previous studies, study their protective effects against high LET radiation, and uncover the specific mechanisms underlying their protective effects in aspects of biological molecules, cells radiosensitive tissues and also animals. From these studies, we are also aimed to develop novel targets and strategies for prevention and therapy of high LET radiation. This study is not only critical for improving the medical treatment against high LET radiation in marine, it is also very important for radioprotection and therapy for the injuried from nuclear grants accidents and nuclear terrorist attacks.

核动力舰艇是强大海上军事力量的核心作战平台，我国正处于快速发展阶段。研究解决核动力舰艇核辐射防护医学难题，对维护官兵身体健康、挽救伤病员生命、提高战斗力至关重要，是实现海洋军事强国战略亟待解决的重要问题。目前我军尚缺乏防护核动力舰艇核辐射损伤的医学技术，尤其是在高LET辐射、高/低LET混合照射医学防护方面，核辐射对健康影响最受官兵关注，部队反映强烈！针对这一重大战略需求，本项目结合我军核动力舰艇辐射场特征和前期实验结果，拟从预防、治疗和模拟验证三个方面开展深入研究。重点选择具国际前沿的TLRs信号分子、分子氢、新型强抗氧化剂等，从分子、细胞、辐射敏感组织、整体动物等多个层次，系统探索防治核动力舰艇核辐射所致机体损伤的新途径、新靶点和新技术，揭示它们防治核辐射损伤的作用机理。这不仅对提高海军核辐射损伤防护水平有重要意义，而且对核电站事故、核袭击等人员防护和伤病员救治也有巨大的潜在应用价值。

核动力舰艇是强大海上军事力量的核心作战平台，研究解决核动力舰艇核辐射防护医学难题，对维护官兵身体健康、提高战斗力至关重要。本课题在国家自然科学基金重点项目的资助下，根据原计划书内容，通过采用γ射线辐照装置、中子源辐照装置、重离子加速器等建立高LET、高/低LET辐射混合照射辐射损伤生物模型，从预防、治疗和模拟验证三个方面系统探索防治核动力舰艇核辐射损伤的新途径和新技术。.研究发现：1. 发现TLRs靶向配体CPG-ODN、HKST、MPLA，以及虎杖苷、分子氢等对高LET辐射、高/低LET射线混合照射损伤的防治作用，初步阐明了所研究对象防护核辐射损伤的分子机制，其中分子氢、CPG-ODN，Zymosan-A等作用显著且极有研发前景。2. 基于分子氢良好的抗辐射作用，主编《分子氢与健康》书籍1部，对分子氢抗辐射作用进行了科普宣讲；与第三公司合作，得到高浓度分子氢抗辐射保健杯，并应用于一线部队扩试，促进基础研究成果向部队实际应用转化。3. 在项目执行过程中也开展了一些原计划没有列入的工作，如FG-4592、格列苯脲、低氧BMSCs防治辐射损伤新技术研究等；同时构建TLR9 KO 和HIF-2 KO等KO小鼠以丰富和完善课题组TLR与HIF研究平台，并构建ZDHHC15 CKO小鼠对TLR下游潜在辐射损伤防治新靶点ZDHHC15进行了部分研究。.总之，本项目结合我军核动力舰艇辐射场特征，从预防、治疗和模拟验证三个方面系统探索防治核动力舰艇核辐射损伤的新途径和新技术。目前已经成文标注本基金号发表论文27篇，申报国家专利 21项，授权9项；培养博士8名，硕士7名；项目组成员2人晋升为教授，3人晋升为副教授，1人晋升为高级实验师；受邀在国内外学术做大会报告7次；项目负责人获国家科技进步一等奖1 项（2018-2），顺利圆满地完成了本项目。总体执行情况良好。