AMS测定41Ca及其在生物医学中的应用

1Ca accelerator mass spectrometry measurement method has been setup at the China Institute of Atomic Energy. A sensitivity of about 10-14 was obtaint by using standard samples. The first determination of 41Ca in cell sample indicates that 41Ca tracing can be used for investigation of Ca2+ cell messenger, for study Ca2+ messenger related cancer caused by C.S. and Ca2+ related with any other cell problems.

钙是人体重要元素，它除了与多种疾病相联系外，近年来发现当致癌物与细胞相互作用引起细胞增殖过程中，胞浆内游离Ca2+浓度不断增加。为了查明Ca2+增加在细胞增殖中的作用，本项目以41Ca作为示踪剂，以AMS方法为测量手段，测定在致癌物作用下细胞增殖过程中胞贑a2+浓度增加的来源，从而可能为研究致癌物引发癌症的机理提供重要依据。