PPARγ和β-catenin对HBV相关性肝癌发生的作用机制研究
基本信息
结项摘要
HBx作为一种反式作用因子，通过作用于肝细胞内多种转录、基因调控因子，影响肝细胞的增殖和凋亡，与原发性肝癌的发生发展密切相关。我们前期研究发现HBx使肝细胞中?-catenin的表达量增加以及定位发生改变，并且肝细胞中PPARγ能抑制?-catenin的表达，这就促使我们希望了解HBx、?-catenin和PPARγ在HBV相关性肝癌的发生过程中的作用以及相互关系。本课题拟通过基因转染HBx、PPARγ、?-catenin，利用PPARγ特异配体的激活作用，从体内和体外研究HBx、PPARγ和?-catenin之间的相互作用,探讨HBx在原发性肝癌发生过程中的信号转导机制，为肝癌发生机理和生物治疗的研究提供理论基础和实验依据。
项目摘要
项目成果
{{i.achievement_title}}
{{i.achievement_title}}
暂无此项成果
数据更新时间：2023-05-31
其他相关文献
Mechanical vibration mitigates the decrease of bone quantity and bone quality of leptin receptor-deficient db/db mice by promoting bone formation and inhibiting bone resorption.
Mechanical vibration mitigates the decrease of bone quantity and bone quality of leptin receptor-deficient db/db mice by promoting bone formation and inhibiting bone resorption.
TRAF4, a new substrate of SIAH1, participates in chemotherapy resistance of breast cancer cell by counteracting SIAH1‑mediated downregulation of β‑catenin
TRAF4, a new substrate of SIAH1, participates in chemotherapy resistance of breast cancer cell by counteracting SIAH1‑mediated downregulation of β‑catenin
L-Carnitine Is Involved in Hyperbaric Oxygen-Mediated Therapeutic Effects in High Fat Diet-Induced Lipid Metabolism Dysfunction
L-Carnitine Is Involved in Hyperbaric Oxygen-Mediated Therapeutic Effects in High Fat Diet-Induced Lipid Metabolism Dysfunction
Fatty acid-binding protein 5 aggravates pulmonary artery fibrosis in pulmonary hypertension secondary to left heart disease via activating wnt/β-catenin pathway
Fatty acid-binding protein 5 aggravates pulmonary artery fibrosis in pulmonary hypertension secondary to left heart disease via activating wnt/β-catenin pathway
Ordinal space projection learning via neighbor classes representation
Ordinal space projection learning via neighbor classes representation
冯涛的其他基金
相似国自然基金
MVP在HBV相关性肝癌发生发展中的作用及机制研究
广西肝癌高发区MC-LR污染与HBV变异对肝癌发生的协同作用与机制研究
以HBV转基因鼠肝癌模型探讨肝癌发生的分子机制
preS1调控GP73/NF-κB信号通路导致HBV相关性肝癌发生发展的作用机制研究