TRX及其信号调节通路在动脉粥样硬化发生与发展中的作用
基本信息
结项摘要
动脉粥样硬化(As)发生的氧化应急/炎症假说仍是关注的热点。硫氧还蛋白TRX作为氧化还原调节关键分子调节细胞内信号转导发挥组织抗炎作用。我们前期的工作提示TRX可能在As的发生中起重要的调节作用。本研究拟在已有工作基础上，将TRX+/-基因敲除鼠和TRXTg转基因鼠与apoE基因敲除鼠（apoE-/-）杂交，产生新的TRX+/-/apoE-/-联合缺陷鼠和TRXTg/apoE-/-鼠，或apoE-
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数据更新时间：2023-05-31
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