SAH在蛋氨酸促进动脉粥样硬化形成中的作用与DNA甲基化的关系
基本信息
结项摘要
动脉粥样硬化(As)是严重危害人类健康的血管疾病。已往研究认为膳食摄入高蛋氨酸(Met)促进As的发展是其代谢产物同型半胱氨酸（Hcy）的作用，但近年有研究结果显示Met的另一代谢中间产物（SAH）在其中发挥更重要的作用，而Hcy可能只是其中的一个伴随现象。Met代谢过程中脱去的甲基是DNA、RNA等大分子甲基化的主要供体。基因异常甲基化与As等慢性疾病的发展密切相关。高Met摄入是否影响As相关
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数据更新时间：2023-05-31
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