β2微球蛋白淀粉样沉积的募集机制及生物学作用
基本信息
结项摘要
课题完成了β2微球蛋白（β2 m）募集机制和生物学作用的研究。主要结果①首次证实β2m通过与晚期糖基化终产物（AGEs）修饰的胶原的结合在关节选择性沉积并在原位被AGEs修饰（“原位修饰学说”）；②AGEs-β2m上调关节滑膜和微血管内皮细胞粘附分子表达并影响滑膜细胞的贴附、伸展和生长；③AGEs-β2m通过受体介导的途径影响人成纤维细胞的增殖和I型胶原的转录和翻译；④氨基胍抑制β2m的AGEs修饰，上述结果为透析相关性淀粉样变时β2m淀粉样沉积的形成机制和病理生物学作用提出了新理论。已在国内外核心期刊发表论文18篇。原位修饰学说被写入3本国际经典教科书。两次受邀为国内外著名杂志撰写述评。获美国肾脏病学会奖励1项。已申报部级一等奖。
项目摘要
项目成果
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数据更新时间：2023-05-31
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