硫胺素酶的模拟：超分子催化不对称偶姻缩合反应

Three novel types of thiaminase models, which are chiral imidazole cyclophane, imidazolium or multi-imidazolium and macrocyclic polyamine, have been designed and synthesized.The chiral recognition, the selective anion recognition, the catalytic benzoin condensation and phosphate diester hydrolysis of target compounds have been investigated.These models have mimicked successfully the molecular recognition and some catalytic ability of thiaminase, are efficient biomimetic thiaminase.

以组氨酸作手性源，设计合成新型手性咪唑翁盐构筑的环状以及开链硫胺素酶模型物。深入研究这些受体分子与底物醛之间的分子识别作用以及在此基础之上的超分子催化不对称偶姻综合反应，模拟硫胺素酶的选择性催化性能。阐明结构、构型、非共价相互作用与仿酶催化的关系及作用机制。