基因生物信息系统多尺度结构的复杂性研究

Life system is a typical complex system, for which the information for.biological regulation and molecular structure and function may be associated with the complexity of multi-scale density distribution of the 4 nucleotides along DNA chain.The sequence data provide interesting information for the investigation on the complex function of organisms and for the understanding of the origin and evolution of life as well as the regulation of biological processes. The theory of hierarchical structure was.applied to the analysis of the genome sequence of some species, and a hierarchically similar density distribution of bases and base combinations from the genomes was.obtained. Furthermore, a new method was found for efficient and accurate.characterization of coding sequences. An algorithm called Multivariate Entropy Distance (MED) was developed for gene prediction in microbial genomes. More application of MED method is under studying for the investigation of eukaryotic gene structure and regulation information in genomes.K

基因信息系统是涉及到多个空间尺度结构（染色体、基因组、核酸、蛋白质等）的复杂系统。人类基因组工程的下期重点将是如何在这种复杂系统中提取有意义的信息。我们将应用复杂性研究新成果－－湍湍层次结构理论来分析基因序列，建立相应的基因信息系统层次结构理论，揭示其普适规律并为人类基因组序列分析解读建立必需的复杂性理论。.