1，25二羟维生素D3 靶控ER基因导入联合他莫昔芬对表型转化ER阴性乳腺癌细胞的效应研究
基本信息
结项摘要
研究表明乳腺组织雌激素受体（ER）水平与乳腺癌的发生和治疗预后密切相关。他莫昔芬（TAM）对ER(+)乳腺癌的治疗效果理想，但对ER(-)患者效果甚微,延长服药时间或加大剂量都易诱发子宫内膜癌产生。目前1,25(OH)2D3的抗瘤效应倍受关注,但高钙血症限制了其使用。本研究通过构建一新型ER表达载体，使ER表达受控于维生素D反应元件（VDRE）紧密连接的TK启动子，将其转染ER(-)乳腺癌细胞，利
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数据更新时间：2023-05-31
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