新农药创制基础研究

Guided by molecular biology, molecular mechanics and receptor.theory, applying new methods such as computer-aided molecular design and.combinatorial chemistry, a comprehensive research for agro-bioactive molecules.were undertaken during the last four years. A systematic endeavor for organic and.bio-organic syntheses was persistently undertaken. The relating structure/activity.relationship and computerized calculation were further investigated. Through.bio-screening, a series of lead compounds were found, the project provided an.approach to study basic theory of pesticide science for the purpose of innovation.research for novel environmental-benign pesticides.

拟选择若干个重要病、虫、草害靶标为重点，采用有机合成方法学、分子生物学、分子力学、受授体学说、作用机理、计算机辅助分子设计等多途径，系统开展新农药的基础理论研究，通过设计--合成--生测--生物学研究--再设计--再合成的循环，以期筛选出具有应用前景的候选化合物，为我国农药创制研究作贡献。