阻塞性睡眠呼吸暂停低通气综合征的病理生理表型研究

Obstructive sleep apnea hypopnea syndrom (OSAHS) is the most common sleep breathing disordered. The first line therapy for OSAHS is continuous positive airway pressure(CPAP),but the adherence is poor. The key issue of finding the new treatment methods and ideas are studying the pathogenesis of OSAHS. The latest research suggests a new individualized therapy model according to different pathophysiological phenotype. None of researches about the pathophysiological phenotype of OSAHS were published in Chinese population. We plan to explore the method of measuring OSAHS pathophysiology phenotype using physiology polysomnogram(PSG), quantifying different physical variables of OSAHS applying the standard PSG, analyzing the OSAHS pathophysiology phenotype with standard PSG and furthermore, studying the relationship of different pathophysiological phenotype and candidate genes of OSAHS so as to understanding the pathogenesis of OSAHS much further.

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是最常见的睡眠呼吸疾病，一线治疗持续气道正压通气治疗(CPAP)依从性差，探索新的治疗方法和理念需要更深入地研究OSAHS的发病机制。最新的研究提出根据不同的病理生理表型选择个体化的新的治疗模式。目前国内尚缺乏OSAHS病理生理表型的相关研究。本研究拟在国人中应用生理多导睡眠图探索测量OSAHS的病理生理表型的方法，并研究应用标准多导睡眠图量化OSAHS不同的生理变量的方法，应用标准多导睡眠图来进行OSAHS患者的病理生理表型分析，进一步探索不同病理生理表型的OSAHS与候选基因的关系，从而深入研究OSAHS发病机制。

阻塞性睡眠呼吸暂停（OSA)一种异质性疾病，病理生理机制复杂，临床表型多样，一线治疗持续气道正压通气治疗(CPAP)依从性差，根据不同的病理生理表型和临床表型选择个体化是新的治疗思路。本研究评价发现了不同临床表型的OSA具有不同的病理生理特点，肥胖的OSA肺功能相对低；伴有高碳酸血症的OSA需警惕神经肌肉疾病；OSA患者的经鼻一氧化氮水平与鼻腔炎症有关；不同觉醒阈值的OSA有着不同的血脂、血糖水平和炎症指标；不同临床表型的呼吸暂停低通气指数和觉醒阈值无显著差别，但血糖、血脂和炎症标志物存在差别。我们的结果提示可以临床表型、生物标志物为切入点，探索其中的病理生理表型，为个体化治疗提供依据。