生藤抗癌活性成分的研究

After screening the anticancer activity of many Chinese herbal drug, we found Stelmatocrypton khasianum (Benth.) H. Bail. and Carduus cripus L. have anticancer activity. And then lipid fractions of Stelmatocrypton khasianum and alkaloid fraction from Carduus cripus showed remarkable activities. From the active fractions 45 compounds have been isolated by chromatography methods and the structures were identified on the basis of spectroscopic methods. Among them 12 compounds are new compounds. A graduate student has been trained and 7 papers have been published and 1 paper was accepted, 3 of the papers have been recorded in SCI.

生藤为萝摩科须药藤属独种植物，主产于我国，在世界范围内仅印度有些分布。该课题拟对生藤的化学成分，特别是抗癌活性成分进行研究。应用现代色谱及波谱方法分离鉴定活性成分，采用先进的细胞和分子水平技术发现活性成分，用化学方法优化结构，研究其构效关系和作用机理，为发现抗癌先导化合物和研制抗癌新型药物提供科学依据。. .