膳食n-3多不饱和脂肪酸对中国2型糖尿病患者血糖和胰岛素抵抗的影响及机理研究

基本信息
批准号:81273054
项目类别:面上项目
资助金额:75.00
负责人:李铎
学科分类:
依托单位:浙江大学
批准年份:2012
结题年份:2016
起止时间:2013-01-01 - 2016-12-31
项目状态: 已结题
项目参与者:MarkLWahlqvist,黄涛,郑钜圣,高金龙,付元庆,李克磊
关键词:
2型糖尿病胰岛素抵抗临床试验血糖n3多不饱和脂肪酸
结项摘要

Type 2 diabetes (T2D) was one of the most common chronic diseases in the world. Dietary n-3 polyunsaturated fatty acids (n-3 PUFA) might decrease risk of T2D in Asians, and plasma phospholipids n-3PUFA were positively associated with insulin sensitivity in Chinese T2D patients. However, there were no randomized clinical trials examining the relationships between n-3 PUFA supplementation and glucose and insulin resistance in Chinese T2D patients. This study is a double-blinded randomized placebo-controlled clinical trial, we will recruit 240 Chinese T2D patients and all of them will be randomized into three groups: tuna oil (n = 80, 3g/d/head), flaxseed oil (n = 80, 3g/d/head) and corn oil (n = 80, 3g/d/head). The intervention will last for 180 days. The primary aim of this study is to examine the effects of n-3 PUFA on glucose and insulin resistance in Chinese T2D patients. The interaction of n-3 PUFA with genetic variants of key genes in the Insulin/IGF-1 signalling pathways on glucose and insulin resistance will be explored. Finally, rat model and cell culture experiments will be used to further explore the effects of n-3 PUFA on the mRNA and protein expressions of key genes in Insulin/IGF-1 pathways. This study is important for the advancement of personalized nutritional therapy for Chinese T2D patients.

血浆磷脂n-3多不饱和脂肪酸(n-3 PUFA)与中国2型糖尿病患者的胰岛素敏感性呈显著正相关,但目前尚无随机对照试验研究膳食n-3 PUFA对中国2型糖尿病患者血糖和胰岛素抵抗的影响。本项目采用双盲随机对照方法,拟征集240名2型糖尿病患者,随机分为金枪鱼油(n=80, 3g/日/人)、亚麻籽油(n=80, 3g/日/人)和玉米油(n=80,3g/日/人)三个组干预180天。主要研究n-3 PUFA对中国2型糖尿病患者血糖和胰岛素抵抗的影响;探索n-3 PUFA与Insulin/IGF-1信号通路中关键基因的多态性产生的交互作用。同时,利用大鼠实验和细胞实验进一步研究n-3 PUFA对该通路关键酶活性和关键基因mRNA表达和蛋白表达的影响。本研究对于推动中国2型糖尿病患者的个性化营养治疗具有重要意义。

项目摘要

海洋n-3多不饱和脂肪酸对中国2型糖尿病患者血糖代谢和胰岛素抵抗的影响及相关机理并不明确。本研究的目的是通过双盲随机对照试验探索n-3多不饱和脂肪酸对中国2型糖尿病患者血糖代谢和胰岛素抵抗的影响,并通过代谢组学和动物模型探索相关机理。首先,本研究通过双盲随机对照试验,发现在中国2型糖尿病患者中,深海鱼油相对于玉米油对照能够显著降低空腹糖化血红蛋白的浓度(P=0.037),从而起到调节血糖代谢的作用;同时,代谢组学分析显示,呋喃代谢物CMPF是深海鱼油干预的最强生物标志物。大鼠实验表明,深海鱼油能够通过调节胰岛素通路上的关键基因mRNA表达来调节胰岛素敏感性水平。本项研究结果对于中国2型糖尿病患者的营养治疗具有重要意义。

项目成果
{{index+1}}

{{i.achievement_title}}

{{i.achievement_title}}

DOI:{{i.doi}}
发表时间:{{i.publish_year}}

暂无此项成果

数据更新时间:2023-05-31

其他相关文献

1

High Performance Van der Waals Graphene-WS2-Si Heterostructure Photodetector

High Performance Van der Waals Graphene-WS2-Si Heterostructure Photodetector

DOI:10.1002/admi.201901304
发表时间:2019
2

中温固体氧化物燃料电池复合阴极材料LaBiMn_2O_6-Sm_(0.2)Ce_(0.8)O_(1.9)的制备与电化学性质

中温固体氧化物燃料电池复合阴极材料LaBiMn_2O_6-Sm_(0.2)Ce_(0.8)O_(1.9)的制备与电化学性质

DOI:10.11862/CJIC.2019.081
发表时间:2019
3

Enhanced piezoelectric properties of Mn-modified Bi5Ti3FeO15 for high-temperature applications

Enhanced piezoelectric properties of Mn-modified Bi5Ti3FeO15 for high-temperature applications

DOI:10.1111/jace.16978
发表时间:2020
4

Influence of calcination temperature on the photocatalytic performance of the hierarchical TiO2 pinecone-like structure decorated with CdS nanoparticles

Influence of calcination temperature on the photocatalytic performance of the hierarchical TiO2 pinecone-like structure decorated with CdS nanoparticles

DOI:https://doi.org/10.1016/j.ceramint.2018.09.243
发表时间:2018
5

Functionalization and Fabrication of Soluble Polymers of Intrinsic Microporosity for CO2 Transformation and Uranium Extraction

Functionalization and Fabrication of Soluble Polymers of Intrinsic Microporosity for CO2 Transformation and Uranium Extraction

DOI:
发表时间:2018

相似国自然基金

1

n-3多不饱和脂肪酸和irisin对妊娠糖尿病患者产后发生糖代谢异常的影响及机制

批准号:81602862
批准年份:2016
负责人:蔡莉
学科分类:H3005
资助金额:17.00
项目类别:青年科学基金项目
2

n-3多不饱和脂肪酸体外和体内抗乳腺癌机理研究

批准号:81102121
批准年份:2011
负责人:邹祖全
学科分类:H3003
资助金额:23.00
项目类别:青年科学基金项目
3

n-3多不饱和脂肪酸对高脂饮食小鼠精子tsRNAs表达和修饰的影响及作用机制研究

批准号:31701308
批准年份:2017
负责人:曹忠红
学科分类:C1208
资助金额:25.00
项目类别:青年科学基金项目
4

膳食脂肪酸与FADS基因多态性对乳汁多不饱和脂肪酸水平及婴儿智力的影响

批准号:81102115
批准年份:2011
负责人:谢林
学科分类:H3003
资助金额:23.00
项目类别:青年科学基金项目