微流控可控制备Janus纳米颗粒及其稳定的微气泡分散体系传质强化与高效给氧的研究

To achieve intravenous oxygen delivery, developing stable microbubble dispersions, which could speed up the delivery of oxygen to blood, is very important. In this project, we use microfluidic to fabricate biocompatible Janus nanoparticles with desired properties and use them to stabilize microbubble dispersions, which could enhance the mass transfer of oxygen across the gas/liquid interface and achieve intravenous oxygen delivery. The project will study the effects of enhanced mixing within microchannels on the properties of Janus nanoparticles. The equilibrium state of Janus nanoparticles will be analyzed based on the spreading coefficients and the surface tensions. The behavior of Janus nanoparticles stabilizing the gas/liquid interface will be investigated in detail to prepare stable microbubble dispersions. We will also measure the mass transfer performance of oxygen across the gas/liquid interface stabilized by Janus nanoparticles and unveil its underlying mechanism. The project will enrich the study of dispersion and mass transfer between gas and liquid in microsystem and pave the way for the development of novel gas/liquid disperse systems and the application of intravenous oxygen delivery.

针对静脉高效给氧，开发稳定分散的微气泡气系，实现血液中氧气含量的快速提高具有重要意义。本项目将利用微流控可控制备生物相容的Janus纳米颗粒，通过Janus纳米颗粒稳定微气泡分散体系，强化气液相间氧气传质过程，实现静脉高效给氧。将重点研究微通道中液液两相混合强化传质速率对Janus纳米颗粒尺寸的调控规律；通过扩展系数和三相界面张力平衡，分析Janus纳米颗粒的热力学平衡态，建立预测Janus颗粒形貌结构的数学模型；探索Janus纳米颗粒在气液界面的行为及其稳定气液界面的内在机理，制备稳定分散的微气泡体系；揭示Janus纳米颗粒稳定的微气泡分散体系强化气液相间氧气传质过程的内在机理和调控规律。本项目的研究将丰富微尺度条件下气液两相分散和传递过程的基本理论，为发展新型高效的气液微分散传质过程、实现静脉高效给氧提供基础。

针对静脉高效给氧，开发稳定分散的微气泡气系，实现血液中氧气含量的快速提高具有重要意义。本项目将利用微流控可控制备生物相容的Janus纳米颗粒，通过Janus纳米颗粒稳定微气泡分散体系，强化气液相间氧气传质过程，实现静脉高效给氧。将重点研究微通道中液液两相混合强化传质速率对Janus纳米颗粒尺寸的调控规律；通过扩展系数和三相界面张力平衡，分析Janus纳米颗粒的热力学平衡态，建立预测Janus颗粒形貌结构的数学模型；探索Janus纳米颗粒在气液界面的行为及其稳定气液界面的内在机理，制备稳定分散的微气泡体系；揭示Janus纳米颗粒稳定的微气泡分散体系强化气液相间氧气传质过程的内在机理和调控规律。本项目的研究将丰富微尺度条件下气液两相分散和传递过程的基本理论，为发展新型高效的气液微分散传质过程、实现静脉高效给氧提供基础。