防治中药材病虫害的杂环多元烯酸衍生物

It is for a long period that there have been no efficient countermeasures against serious insects, weeds and plant disease of Chinese herbs. Thus the scale, characteristic and classification of pests, weeds and diseases of 55 herbs in Guizhou province were investigated in this project..Taking tung oil acid, other poly unsaturated acid and heterocycles as lead compound, followed by lead optimization and lead development, 40 new compounds were designed and synthesized. Their bioactivity were tested against the main herb damagers such as Rhizoctonia, Fusarium wilt, Plant Virus, Alternaria, Leaf spot disease, Aulacorthum sp, Rottemberg, Linnaeus. The bioactive compounds were obtained and the structure-activity relationship was investigated, which give good bases for the following new bionic pesticide formulating..The pesticide residue detect lab was established to monitor the pesticide residue status of Chinese herbs in Guizhou province. Several research papers were published. Six masters of science graduated and one Ph.D. did research work by the financially support of the fund as well. .

以桐油酸或多元烯酸与杂环为研究对象,进行先导设计和先导优化,设计与仿生合成一盗形粗衔?以中草药重要病虫害为试验对象筛选具有高效生物活性、作用机制新颖、环境友好的生物合理农药..............