2型糖尿病易感基因PGC-1α的分子遗传机理研究
基本信息
结项摘要
骨骼肌细胞中特异表达的PGC-1α在糖尿病（DM）的胰岛素抵抗（IR）发生机制中起着关键作用。为阐明其在DM中的分子机制和生物学意义，研究策略拟采用两条线路，即组合基因组和转录组水平同步进行研究。分别通过第一步经典分子遗传学的家系分离，遗传模式分析和群体病例对照研究阐明有意义的突变基因型，再通过突变细胞分子功能的对比研究来认证。第二步阐明DM骨骼肌细胞中PGC-1α下调的机制，证明这种下调机制是与
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数据更新时间：2023-05-31
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