HIV感染者主要免疫细胞比例动态变化与疾病进展的相关性研究

After HIV enters into the human body, it mainly infects T lymphocytes, monocyte- macrophages, B lymphocytes and NK cells, etc. We find from clinical practice that the counting of CD4+T lymphocytes doesn't symbolize the increase or decrease of immune function; and we observe that a lot of patients don't have the other AIDS symptoms and signs for more than two years while the counting of CD4 lymphocytes is less than 350 after they purely accept the treatment with TCM without anti-viral treatment, so we put forward such an assumption that an important reason for no development of AIDS with the counting of CD4 lymphocytes being less than 350 is that the counting of the HIV infected patients' main immune cells is low but the proportion of all kinds of main immune cells is in a state of equilibrium like normal people. Therefore, this research will dynamically observe the proportion of all kinds of main immune cells of the patients who don't have the other AIDS symptoms and signs for more than two years while the counting of CD4 lymphocytes is less than 350 after they purely accept the treatment with TCM without anti-viral treatment, refer to the proportion of all kinds of main immune cells of the normal people and the patients who are in the treatment group of TCM and western medicine and in the treatment group of pure HAART, explore the correlation between the dynamic situation of the proportion of various cells in the immune system, the disease progression of HIV infected patients and the whole function of immune system, and find and put forward the imunological indicators for HIV/AIDS curative effect evaluation with the characteristics of TCM, thereby providing support on basic research of clinical application for AIDS treatment with TCM.

HIV进入人体后主要感染T淋巴细胞,单核-巨噬细胞,B淋巴细胞,NK细胞等。临床实践发现CD4+T淋巴细胞计数的高低并不是患者免疫功能高下的标志；我们观察到对于不愿接受抗病毒治疗，单纯采用纯中药治疗,CD4记数小于350时间超过2年以上而并未出现其它艾滋病期症状体征的病人亦不少，我们分析提出这样一种假说， HIV感染者主要免疫细胞记数低但各类主要免疫细胞比例处于常人一样的平衡状态，也是CD4记数小于350但却不发病的一个重要原因。基于此，本研究拟对CD4记数小于350时间超过2年以上而未出现其它艾滋病期症状体征的病人的各类主要免疫细胞的比例状态进行动态观测，并与正常人、中西医结合和纯HAART治疗的病人的进行参照，探索HIV感染者免疫系统各类细胞比例动态情况与疾病进展、免疫系统整体功能的相关性，发现并提出中医药特色的艾滋病疗效评价免疫学指标，为中医药治疗艾滋病提供临床应用基础研究的支撑。

HIV进入人体后主要感染T淋巴细胞,单核-巨噬细胞,B淋巴细胞,NK细胞等。临床实践发现CD4+T淋巴细胞计数的高低并不是患者免疫功能高下的标志；我们观察到对于不愿接受抗病毒治疗，单纯采用纯中药治疗,CD4记数小于350时间超过2年以上而并未出现其它艾滋病期症状体征的病人亦不少，我们分析提出这样一种假说， HIV感染者主要免疫细胞记数低但各类主要免疫细胞比例处于常人一样的平衡状态，也是CD4记数小于350但却不发病的一个重要原因。基于此，本研究拟对CD4记数小于350时间超过2年以上而未出现其它艾滋病期症状体征的病人的各类主要免疫细胞的比例状态进行动态观测，并与正常人、中西医结合和纯HAART治疗的病人的进行参照，探索HIV感染者免疫系统各类细胞比例动态情况与疾病进展、免疫系统整体功能的相关性，发现并提出中医药特色的艾滋病疗效评价免疫学指标，为中医药治疗艾滋病提供临床应用基础研究的支撑。.研究结果显示，CD4计数水平不同，单纯采用纯中药治疗的病人、正常人、中西医结合和纯HAART治疗的病人之间的T淋巴细胞、NK细胞所占比例变化差异性不大；正常人、单纯采用纯中药治疗的病人、中西医结合和纯HAART治疗的病人的B淋巴细胞、单核-巨噬细胞所占比例差异具有显著性，并且有着逐步增高的趋势。同时，中药干预治疗，可以稳定HIV感染者各类主要免疫细胞比例，使其更接近正常人一样的平衡状态的各类主要免疫细胞比例。初步研究表明，HIV感染者疾病进展、疾病分期、免疫系统整体功能与免疫系统各类细胞比例变化有一定关系，尤其与B淋巴细胞、单核-巨噬细胞比例变化更具相关性。