铁基多元异质结材料用于肿瘤化学动力学疗法的研究

Searching for more efficient tumor therapies that based absolutely on the unique micro-environment in the tumor to avoid the inherent defect of the conventional therapies are a focus in the recent studies in the fields of functional materials and cancer therapy. In this project, we devoted to designing and synthesizing iron-based heterostructures as tumor chemodynamic therapy (CDT) agents on the basis of the CDT principle and the unique tumor micro-environment. The CDT efficiency from the aspects of the microstructures and the compositions and the structures of the heterostructures will be systematically studied to understand the inner mechanism of the CDT. In order to further improve the CDT efficiency, we will bring the green ultrasonic techniques which could promote the Fenton reaction in consequence of its cavitation effect. It is worth noting that the gene silencing technique is hopeful to transform the tumor microenvironment to accommodate the best condition for Fenton reaction. It will provide new ideas to solve the tumor recur and metastasis problems by the synergistic interactions of CDT and the gene silencing. We believe of the new CDT technique based on the tumor micro-environment will play an important role in promoting the application of biochemistry in the clinical medicine research.

如何充分利用肿瘤特异性微环境，发展新型高效的肿瘤治疗技术，克服常规肿瘤治疗技术的固有缺陷，实现低毒副作用的高效治疗，是当前肿瘤治疗研究领域的前沿热点。本项目拟从新型“化学动力学疗法（Chemodynamic Therapy, CDT）”的原理出发，结合肿瘤特异性微环境，设计合成系列新型铁基多元异质结纳米诊疗剂，从材料结构和组成角度系统探究材料对CDT疗法的影响，提出CDT疗法的内在作用机理。同时，为进一步增强CDT治疗效果，拟联合生物安全性高的超声技术，探索超声空化效应对CDT疗法的协同增效机理；并探索基因沉默技术与CDT疗法协同治疗肿瘤的新策略，从源头上寻求实现高效CDT肿瘤治疗的有效方法。这类基于肿瘤特异性微环境诱导激活的新型CDT治疗技术，对推动和发展材料科学和化学生物学在临床医学中的应用具有重要意义。

本项目从新型“化学动力学疗法（Chemodynamic.Therapy,.CDT）”的原理出发，结合肿瘤特异性微环境，设计合成系列新型铁基多元异质结纳米诊疗剂，从材料结构和组成角度系统探究材料对 CDT疗法的影响，揭示了CDT疗法的内在作用机理。同时，为进一步增强CDT治疗效果，联合超声技术，探索超声空化效应对CDT疗法的协同增效机理；并利用基因转录组学技术与CDT疗法协同治疗肿瘤的新策略，从源头上寻求实现高效CDT肿瘤治疗的有效方法。项目执行期共发表SCI论文33篇（其中，27篇影响因子大于15；31篇影响因子大于10.0）；申请发明专利8项。这类基于肿瘤特异性微环境诱导激活的新型CDT治疗技术，对推动和发展材料科学和化学生物学在临床医学中的应用具有重要意义。