抑制脂肪肝解偶联蛋白-2表达提高肝移植成功率的作用及机制
基本信息
结项摘要
临床肝移植时，若供肝为脂肪肝常并发移植后肝原发无功能，导致患者死亡或再次肝移植，如何降低其移植后原发无功能发生是目前亟待解决的关键问题。本项目在原有工作基础上,拟构建靶向调控脂肪肝中解偶联蛋白-2（UCP-2）表达并与逆转录病毒体重组的质粒，在正常与肥胖小鼠（肝脂肪含量约70%-80%）体外培养肝细胞、缺血/再灌注及移植模型中转染。采用荧光素酶法、速率法、RT-PCR、Western blot、流
项目摘要
项目成果
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暂无此项成果
数据更新时间：2023-05-31
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