以辣椒素受体为靶点抗肝纤维化作用的研究
基本信息
结项摘要
因多种原因引起的慢性肝损伤而导致的肝纤维化是诸多肝脏疾病的共同病理基础，也是肝癌癌变过程中的重要阶段。辣椒素受体（vanilloid receptor-1，VR1；又称TRPV 1）既可被内源性大麻素物质如AEA,也可被辣椒中的主要辛辣成分Capsaicin激活。申请者在发现大麻素受体（CB1和CB2）、辣椒素受体及其同源受体TRPV2在肝癌及肝硬化的表达作用的基础上，拟从细胞与整体水平进一步探讨辣椒素受体的激动剂Capsaicin的抗肝纤维化的作用；从辣椒素受体，大麻素受体，细胞增殖、凋亡、氧化应激、细胞外基质及相关信号调节等方面揭示辣椒素受体激动剂Capsaicin 抑制肝纤维化的分子作用机制以及与大麻素受体在肝纤维化中的相关关系。本项目研究既是上一个国家自然科学基金项目内容的系统补充，又是阐明肝纤维化发生机制的新的拓展。
项目摘要
项目成果
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数据更新时间：2023-05-31
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