tPA/PAI.2对人胚胎期角朊细胞分化作用的研究
基本信息
结项摘要
目前常用的表皮角朊细胞培养研究模型和皮肤原位组织中tPA和含量较低，难以检测，作者建立了人胚胎期表皮角朊细胞培养模型，解决了这一难点。利用细胞因子和生物因子对tPA/PAI-2作用研究的进行。本研究课题还发现，tPA/PAI-2主要作用于终未分化的角朊细胞；表皮中tPA含量低于PAI-2含量；孕中期的角朊细胞中tPA/PAI-2的含量比其他胎龄期高；表此中某些因子如IGF、Nexin1和TNF-2等对分化中角朊细胞的tPA/PAI-2有正向式负向调节作用，初步工作提示，这些因子间高能是处于一个自分泌样环中。本研究提示，tPA/PAI-2是角朊细胞分化调节键中重要的一环。
项目摘要
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数据更新时间：2023-05-31
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