THAP11的促凋亡作用及其分子机制研究
基本信息
结项摘要
THAP11具有THAP结构域，是新发现THAP蛋白家族的成员之一。我们前期实验发现THAP11具有抑制NF-κB活化，引起肿瘤细胞凋亡的作用。本项目拟通过建立可稳定诱导表达细胞株，评价THAP11的促凋亡作用，并对THAP11结构与功能关系进行研究；探讨THAP11抑制NF-κB活化及在诱导凋亡中的作用，并对THAP11抑制NF-κB活化的分子机制及其调控机理进行深入的研究。这不仅有助于阐明THAP蛋白家族的重要生物学功能，而且可以更深入地认识和理解凋亡的调控机理，并可能对包括白血病在内的多种肿瘤提供新的临床药物作用靶点。
项目摘要
项目成果
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数据更新时间：2023-05-31
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