乳腺癌细胞中REGgamma的新生物靶位点研究
基本信息
结项摘要
与其他恶性肿瘤一样，乳腺癌至今都没有发现一种高效、特异的抗癌治疗目靶。研究发现REGgamma/20s蛋白酶体通路与乳腺癌细胞的生长、细胞周期和凋亡密切相关，REG/20s蛋白酶体复合物可能作为一种有效而令人鼓舞的抗癌治疗的目靶。前期研究发现REGgamma/20s蛋白酶体对内源性靶蛋白具有降解的作用，突破了REGgamma/20s蛋白酶体仅具有降解短肽链底物的禁区，本项目以REGgamma/20s蛋白酶体通路的生物学功能为研究对象，拟在乳腺癌细胞株中通过质谱法和亲和抗体色谱法找到这些未知的REGgamma靶蛋白，然后通过REGgamma对这些靶蛋白的降解来进一步分析它们的特性和生物学功能,并探讨REGgamma靶蛋白在乳腺癌细胞周期、基因调节和肿瘤发展中的作用。进一步认识REGgammma/蛋白酶体调节乳腺癌细胞生长、细胞周期和凋亡的机制，研究结果将有助于发现新的人类肿瘤的治疗方法。
项目摘要
项目成果
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数据更新时间：2023-05-31
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