基于非共价键相互作用和可控自由基聚合的大分子精密合成

This project will combine the merits of diversity and reversibility of non-covalent interaction(NCI), and handleability and universality of controlled radical polymerization (CRP)to explore a new approach for the synthesis of precisely-controlled macromolecules. By the utlization of proper type of IWP, a monomer-monomer template, monomer-small molecular template or monomer-supporter template is expected to be constructed. The CRP of the templated monomer will generate precisely-controlled macromolecules both in tacticity and monomer sequence. The research will design and prepare the mononmer bearing specific functional group,functional small molecule and supporter. By NCI, i.e., (multi) hydrogen bonding, host-guest inclusion complexation, π-π stacking or electrostatic force, a monomer with bulky group is contructed and then subjected to CRP, which will produce molecular weight and tacticity controlled polymers. By the selection of one type of the above NCI, a bi-monomer or multi-monomer template can be contructed. The CRP of this bi-monomer or multi-monomer template will produce the well-defined macromolecules with controlled molecular weight and monomer sequence. The implementation of this project will explore a new approach for the synthesis of precisely-controlled macromolecules, and eventually enlarge and enrich the methods and approaches for polymer syntheis.

本项目拟结合非共价键相互作用的多样性和可逆性以及可控自由基聚合方法的简便性和适应面广的优点，探索大分子精密合成的新途径。通过选择合适的非共价键相互作用，如：单（多）重氢键、主客体包络识别、π-π 堆积作用、配位作用或离子键间静电力等作用，构建单体-小分子模板、单体-纳米球模板或单体-单体模板；选择合适的可控自由基聚合方法进行聚合，分析和研究聚合行为和规律，最终实现大分子的分子量和立构规整性、分子量和单体单元序列分布的精密可控。本项目的实施将探索大分子结构精密调控和合成的新思路，拓展和丰富高分子合成方法学研究。

本项目结合非共价键相互作用的多样性和可逆性以及可控自由基聚合方法的简便性和适应面广的优点，系统探索了高分子精准合成的新途径。通过选择合适的非共价键相互作用，如：单（多）重氢键作用，构建单体-小分子模板、单体-纳米球模板或单体-单体模板；选择合适的可控自由基聚合方法进行聚合，分析和研究聚合行为和规律，最终实现了大分子的分子量和立构规整性、分子量和单体单元序列分布的精准可控。本项目的实施探索了大分子结构精密调控和合成的新思路，拓展和丰富了高分子合成方法学研究。项目小组根据项目申请书和计划书的要求，严格按年度计划实施研究内容，围绕非共价键辅助的高分子精准合成展开。在项目基金资助下，共发表SCI收录论文11篇，获授权中国发明专利3项，参加国际会议7次。项目资助下，已培养博士毕业研究生1名，硕士研究生4名，完成了项目预定目标。