3D打印自组装血管化股骨头坏死髓芯植入体的构建与性能评价

The bone necrosis process could not be prevented and reversed by the treatment applied on the area of femoral head avascular necrosis in clinical. This group aimed for designing and fabricating a novel core implant based on the structure and mechanical property natural spongy bone. Finite element analysis, fluent analysis and biomechanical analysis will be applied for optimizing the design. Ceramic stereolithography and sintering will be applied for the fabrication. MSC or growth factor could be assembled on the implant. In situ or ectopic, artery and vein could be assembled on the implant by microsurgery techniques. Angiography will be applied for testing the vascularization of the implant. Interventional examination, imaging, histology, molecular biology will be used to evaluate its ability to repair femoral head necrosis. Furthermore, the correlation of ability on vascularization, bone regeneration and microstructure of the implant will be studied. This research will provide a new method to solve the traditional clinical problems on the treatment of femoral head avascular necrosis of young people and to explore the prospect of bionic manufacture based on rapid prototyping technology for the repairing of bone necrosis and bone defect.

针对中、早期股骨头坏死治疗中骨坏死进程难以逆转，甚至于不断加重的问题。本课题组拟以典型骨微观结构和骨微观生物力学特性为基础,构建可预置血管通道的仿生植入体。通过微观有限元分析，流体力学分析，生物力学分析优化模型设计。应用3D打印及高温成型工艺进行制造。选择性进行自体骨髓基质细胞复合/生长因子组装。通过原位/异位预血管化小动静脉显微外科植入构建预置动静脉血流通路的髓芯植入体。微血管造影检测 仿生髓芯植入体自组装血管化功能。介入方法、影像学、组织学、分子生物学检测其对股骨头坏死的修复性能。研究血管化功能，骨修复性能与植入体微结构的理论相关性。探讨仿生结构骨生物材料、血管植入在股骨头坏死修复重建中的作用机制。完善股骨头坏死再血管化的理论，为解决中青年股骨头缺血性坏死这一传统难题提供一种新的方法,拓展基于3D打印的微结构仿生制造技术在骨坏死、骨缺损修复的应用前景。