铁磁微纳介质用于耐药白血病的磁感应靶向热疗及增敏化疗的研究

Chronic myelogenous leukemia will have resistance or multidrug resistance with Glivec and Doxorubicin , which results in high recurrence rate and low control rate after chemotherapy. So a novel treatment technique is really needed. Based on our research of the magnetic materials with micron and nanometer size, we couple specific targeted molecular on its surface. This method can combine medium targeting with cancer cells. Then these cancer cells with magnetic particles can achieve necrosis or sensibilization chemotherapy after being heated under the alternating magnetic field. After decades of our research, magnetic induction thermotherapy technique is already applied to clinical research following Germany, Japan and America. We found that magnetic induction thermotherapy technique mediated by ferromagnetic micron/nano-particles may be a new target therapy or sensibilization chmotherapy to treat resistant leukemia. Based on the previous study on magnetic induction thermotherapy and targeted medium, this research will achieve three tasks. Firstly, it will complete the development of test equipment with high frequency D-type coil by means of magnetocaloric effect model of medium with micron and nanometer size and electromagnetic simulation. Secondly, magnetic materials with micron and nanometer size will be filtrated and specific protein coupled. Thirdly, through the model of leukemia cells with resistance and animals experiments, therapeutic safety and efficiency will be testified. In this project, we explore the possibility of enhancing chemotherapeutic drugs and preliminarily reveal its mechanism. It is the first time to apply the micron/nano-particles mediated magnetic induction thermotherapy technique to treat chronic myelogenous leukemia with resistance in the world. It may make breakthroughs in targeting thermotherapy and enhancement on leukemia with resistance. Further more, it can contribute to our national independent innovation in hematologic neoplasms physicotherapeutics.

慢性粒细胞白血病对格列卫和阿霉素等多药耐药，是白血病治疗失败的主要原因，急需新的治疗技术。我们的前期研究表明，以磁性微纳介质为基体，在表面耦联特异性靶向抗体，再与肿瘤细胞表面特异性受体结合，可实现介质靶向结合肿瘤细胞，置于交变磁场下热疗，达到杀灭或增敏化疗目的。经过十多年研究，我们继德日美后已将磁感应热疗技术推向临床。我们研发的微纳介质磁感应热疗技术可能是耐药性白血病靶向治疗和增敏化疗的新手段。我们拟通过微纳介质磁热效应建模及电磁场仿真，完善高频D型线圈式试验设备研制；筛选高效升温磁性微纳材料，并进行白血病特异性蛋白抗体耦联；通过耐药性白血病细胞和动物模型明确其安全性和有效性，探索该技术增敏化疗的可能性，并初步揭示其作用机理。本课题是国际率先探索微纳介质磁感应热疗应用于慢性粒细胞白血病治疗，可能突破耐药性白血病靶向热疗与增敏治疗技术，为我国自主创新发展血液肿瘤物理治疗新技术提供新思路。

对格列卫和阿霉素等多药耐药，是慢性粒细胞白血病治疗失败的主要原因，急需新的治疗技术。我们的前期研究表明，以磁性微纳介质为基体，在表面耦联特异性靶向抗体，再与肿瘤细胞表面特异性受体结合，可实现介质靶向结合肿瘤细胞，置于交变磁场下热疗，达到杀灭或增敏化疗目的。经过十多年研究，我们继德日美后已将磁感应热疗技术推向临床。.本课题通过四年的研究,进行了微纳介质磁热效应理论研究和模型建立,研制了铁磁性微纳介质诱导升温的D型线圈试验设备,进行了微纳介质制备和表征及生物耦联实验研究,同时还进行了耐药白血病靶向热疗和增敏实验研究与机制探索. 本课题率先探索微纳介质磁感应热疗应用于慢性粒细胞白血病治疗，为我国自主创新发展血液肿瘤物理治疗新技术提供新思路。